Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies

Natural Products and Bioprospecting

Review

Yasir Anwar¹  Bassam Oudh Aljohny¹  Abdur Rauf²  Polrat Wilairatana³  Hassan A. Hemeg⁴  Kumaraswamy Gandla⁵  Md. Rezaul Islam⁶  Muniya Akter⁶  Puja Sutro Dhar⁶  Shopnil Akash⁶  Jeetendra Kumar Gupta⁷  Sabeena Hussain Syed⁸ 

[1]Department of Biological Sciences, Faculty of Science, King Abdulaziz University, 21441, Jeddah, Kingdom of Saudi Arabia

[2]Department of Chemistry, University of Swabi, Anbar, 23561, Khyber Pakhtunkhwa, Pakistan

[3]Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand

[4]Department of Medical Laboratory Technology, College of Applied Medical Sciences, Taibah University, Al-Medinah Al-Monawara, Saudi Arabia

[5]Department of Pharmaceutical Analysis, Chaitanya (Deemed to Be University), Himayath Nagar, 500075, Hyderabad, Telangana, India

[6]Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Daffodil Smart City, Birulia, 1216, Savar, Dhaka, Bangladesh

[7]Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India

[8]School of Pharmacy, Vishwakarma University, Survey No 2, 3,4, Kondhwa Main Rd, Laxmi Nagar, Betal Nagar, Kondhwa, 411048, Pune, Maharashtra, India

关键词: Antihypertensive;    Plants;    Bioactive molecules;    Seafood;    Hypertension;   

DOI  :  10.1007/s13659-023-00411-1

 received in 2023-07-24, accepted in 2023-10-16,  发布年份 2023

来源: Springer

【 摘 要 】

Hypertension (HTN), a complex cardiovascular disease (CVD), significantly impacts global health, prompting a growing interest in complementary and alternative therapeutic approaches. This review article seeks to provide an up-to-date and thorough summary of modern therapeutic techniques for treating HTN, with an emphasis on the molecular mechanisms of action found in substances found in plants, herbs, and seafood. Bioactive molecules have been a significant source of novel therapeutics and are crucial in developing and testing new HTN remedies. Recent advances in science have made it possible to understand the complex molecular mechanisms underlying blood pressure (BP)-regulating effects of these natural substances better. Polyphenols, flavonoids, alkaloids, and peptides are examples of bioactive compounds that have demonstrated promise in influencing several pathways involved in regulating vascular tone, reducing oxidative stress (OS), reducing inflammation, and improving endothelial function. The article explains the vasodilatory, diuretic, and renin–angiotensin–aldosterone system (RAAS) modifying properties of vital plants such as garlic and olive leaf. Phytochemicals from plants are the primary in traditional drug development as models for novel antihypertensive drugs, providing diverse strategies to combat HTN due to their biological actions. The review also discusses the functions of calcium channel blockers originating from natural sources, angiotensin-converting enzyme (ACE) inhibitors, and nitric oxide (NO) donors. Including seafood components in this study demonstrates the increased interest in using bioactive chemicals originating from marine sources to treat HTN. Omega-3 fatty acids, peptides, and minerals obtained from seafood sources have anti-inflammatory, vasodilatory, and antioxidant properties that improve vascular health and control BP. Overall, we discussed the multiple functions of bioactive molecules and seafood components in the treatment of HTN.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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