Injectable biocompatible nanocomposites of Prussian blue nanoparticles and bacterial cellulose as a safe and effective photothermal cancer therapy

Journal of Nanobiotechnology

Research

Hwichan Hong¹  Hoonsub Kim¹  Miyeon Jeon¹  Chaedong Lee¹  MinKyu Kim¹  Wooseung Lee¹  Yuanzhe Piao²  Hyung-Jun Im³ 

[1] Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea;Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea;Advanced Institutes of Convergence Technology, Seoul National University, Suwon-si, Gyeonggi-do, Republic of Korea;Research Institute for Convergence Science, Seoul National University, Seoul, Republic of Korea;Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea;Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea;Cancer Research Institute, Seoul National University, 03080, Seoul, Republic of Korea;Advanced Institutes of Convergence Technology, Seoul National University, Suwon-si, Gyeonggi-do, Republic of Korea;Research Institute for Convergence Science, Seoul National University, Seoul, Republic of Korea;

关键词: Prussian blue nanoparticles;    Bacterial celluloses;    Nanocomposites;    Photothermal therapy;    Improved biocompatibility;   

DOI  :  10.1186/s12951-023-02108-6

 received in 2023-06-02, accepted in 2023-09-15,  发布年份 2023

来源: Springer

【 摘 要 】

Photothermal therapy (PTT) is a novel cancer treatment using a photoabsorber to cause hyperthermia to kill tumors by laser irradiation. Prussian blue nanoparticles (PB NPs) are considered as next-generation photothermal agents due to the facile synthesis and excellent absorption of near-infrared light. Although PB NPs demonstrate remarkable PTT capabilities, their clinical application is limited due to their systemic toxicity. Bacterial cellulose (BC) has been applied to various bio-applications based on its unique properties and biocompatibility. Herein, we design composites with PB NPs and BC as an injectable, highly biocompatible PTT agent (IBC-PB composites). Injectable bacterial cellulose (IBC) is produced through the trituration of BC, with PB NPs synthesized on the IBC surface to prepare IBC-PB composites. IBC-PB composites show in vitro and in vivo photothermal therapeutic effects similar to those of PB NPs but with significantly greater biocompatibility. Specifically, in vitro therapeutic index of IBC-PB composites is 26.5-fold higher than that of PB NPs. Furthermore, unlike PB NPs, IBC-PB composites exhibit no overt toxicity in mice as assessed by blood biochemical analysis and histological images. Hence, it is worth pursuing further research and development of IBC-PB composites as they hold promise as safe and efficacious PTT agents for clinical application.Graphical Abstract

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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