Occupational prestige, social mobility and the association with lung cancer in men

BMC Cancer

Research Article

John McLaughlin¹  Paul Demers¹  David I. Conway²  Lenka Foretova³  Lorenzo Richiardi⁴  Franco Merletti⁴  Lorenzo Simonato⁵  Hans Kromhout⁶  Roel Vermeulen⁶  Cristina Fortes⁷  Vladimir Janout⁸  Jack Siemiatycki⁹  Marie-Elise Parent^1,10  Isabelle Stücker^1,11  Florence Guida^1,11  Karl-Heinz Jöckel^1,12  Isabelle Groß^1,13  Thomas Brüning^1,13  Beate Pesch^1,13  Benjamin Kendzia^1,13  Jan Hovanec^1,13  Thomas Behrens^1,13  David Zaridze^1,14  Per Gustavsson^1,15  Irene Brüske^1,16  Heinz-Erich Wichmann^1,17  Vladimir Bencko^1,18  Kurt Straif^1,19  Joachim Schüz^1,19  Ann Olsson^2,20  Hermann Pohlabeln^2,21  Wolfgang Ahrens^2,22  Adonina Tardón^2,23  Neil Caporaso^2,24  Maria Teresa Landi^2,24  Peter Rudnai^2,25  Rodica Stanescu Dumitru^2,26  Eleonora Fabianova^2,27  John K. Field^2,28  Jolanta Lissowska^2,29  Neonila Szeszenia-Dabrowska^3,30  Paolo Boffetta^3,31  Dario Consonni^3,32 

[1] Cancer Care Ontario, Occupational Cancer Research Centre, Toronto, Canada;Dental School, College of Medicine Veterinary and Life Sciences, University of Glasgow, G2 3JZ, Glasgow, UK;Department of Cancer Epidemiology & Genetics, Masaryk Memorial Cancer Institute and Medical Faculty of Masaryk University, Brno, Czech Republic;Department of Medical Sciences, Unit of Cancer Epidemiology, University of Turin, Turin, Italy;Department of Molecular Medicine, Laboratory of Public Health and Population Studies, University of Padova, Padova, Italy;Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands;Epidemiology Unit, Istituto Dermopatico dell’Immacolata, Rome, Italy;Faculty of Medicine, Palacky University, Olomouc, Czech Republic;Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic;Hospital Research Center (CRCHUM) and School of Public Health, University of Montreal, Montreal, Canada;INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada;Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Environmental Epidemiology of Cancer Team, F-94807, Villejuif, France;University Paris-Sud, UMRS 1018, F-94807, Villejuif, France;Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany;Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany;Institute of Carcinogenesis, Russian Cancer Research Centre, Moscow, Russia;Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany;Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany;Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany;Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic;International Agency for Research on Cancer (IARC), Lyon, France;International Agency for Research on Cancer (IARC), Lyon, France;Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;Leibniz-Institute for Prevention Research and Epidemiology -BIPS GmbH, Bremen, Germany;Leibniz-Institute for Prevention Research and Epidemiology -BIPS GmbH, Bremen, Germany;Institute for Statistics, University Bremen, Bremen, Germany;Molecular Epidemiology of Cancer Unit, University of Oviedo-Ciber de Epidemiologia, CIBERESP, Oviedo, Spain;National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, USA;National Centre for Public Health, Budapest, Hungary;National Institute of Public Health, Bucharest, Romania;Regional Authority of Public Health, Preventive Occupational Medicine, Banska Bystrica, Slovakia;Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Liverpool, UK;Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK;The M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland;The Nofer Institute of Occupational Medicine, Lodz, Poland;The Tisch Cancer Institute and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, USA;Unit of Epidemiology, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, Italy;

关键词: Life course;    Occupational history;    Social prestige;    Socio-economic status;    SYNERGY;    Transitions;   

DOI  :  10.1186/s12885-016-2432-9

 received in 2015-07-27, accepted in 2016-06-10,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case–control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory.MethodsWe included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman’s Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results.ResultsWe observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13–1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32–1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88–1.46 for high to low, and 1.24; 95 % CI 1.08–1.41 for medium to low trajectories.ConclusionsOur results indicate that occupational prestige is independently associated with lung cancer among men.

【 授权许可】

CC BY   
© The Author(s). 2016