Rifampicin resistance in mycobacterium tuberculosis patients using GeneXpert at Livingstone Central Hospital for the year 2015: a cross sectional explorative study

BMC Infectious Diseases

Research Article

Harrison Mubila¹  Sepiso K. Masenga²  Benson M. Hamooya³ 

[1] Chikankata College of Biomedical Sciences, Southern province, Zambia;University of Zambia, School of Health Sciences, P.o Box 50110, Lusaka, Zambia;Pathology Laboratory department, Research section, Livingstone Central Hospital, P.o Box 60091, Livingstone, Zambia;University of Zambia, School of Public Health, P.o Box 50110, Lusaka, Zambia;Pathology Laboratory department, Research section, Livingstone Central Hospital, P.o Box 60091, Livingstone, Zambia;

关键词: Rifampicin resistance;    Mycobacterium tuberculosis;    GeneXpert;   

DOI  :  10.1186/s12879-017-2750-9

 received in 2016-08-25, accepted in 2017-09-19,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSince the recent introduction of GeneXepert for the detection of Tuberculosis (TB) drug resistance mutations in both primary resistance and acquired resistance in Zambia, little has been documented in literature on the issue of rifampicin resistance especially in the face of a high National TB burden. The study aimed to determine the prevalence of rifampicin resistance in tuberculosis patients at Livingstone Central Hospital for the year 2015.MethodsThis was a cross sectional study conducted at Livingstone Central Hospital where we reviewed 152 records (from January 1, 2015 to 31st December, 2015) involving patients who presented with clinically suspected TB or documented TB, whose samples were sent to the laboratory for GeneXpert Mycobacterium tuberculosis/rifampicin testing. Statistical evaluations used a one-sample test of proportion and Fisher’s exact test.ResultsThe age of participants ranged from 8 months to 73 years old (median = 34). Of the participants with complete data on gender, 99 (66%) and 52 (34%) were males and females respectively. The TB co-infection with HIV prevalence was 98.3% (p < 0.001). Prevalence of rifampicin resistance was 5.9% and there was no statistical significant difference between being male or female (p = 0.721).ConclusionWe were able to show from our study, evidence of rifampicin resistance at Livingstone Central Hospital. Hence, there was need for further in-depth research and appropriate interventions (i.e close follow-up and patient care for drug resistance positive patients).

【 授权许可】

CC BY   
© The Author(s). 2017