Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma

Molecular Medicine

Review

Dingyu Rao¹  Zhonghong Lai²  Meijin Liu³  Xiaoying Yuan⁴  Defa Huang⁴  Qing Jin⁴  Haibin Shen⁴ 

[1] Department of Cardiothoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China;Department of Traumatology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China;Ganzhou Jingkai District People’s Hospital, Ganzhou, China;Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China;

关键词: Hepatocellular carcinoma;    Exosomes;    Proliferation;    Migration and transfer;    Diagnosis;    Cellular drug resistance;   

DOI  :  10.1186/s10020-023-00731-5

 received in 2023-07-20, accepted in 2023-09-17,  发布年份 2023

来源: Springer

【 摘 要 】

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is characterized by occult onset resulting in most patients being diagnosed at advanced stages and with poor prognosis. Exosomes are nanoscale vesicles with a lipid bilayer envelope released by various cells under physiological and pathological conditions, which play an important role in the biological information transfer between cells. There is growing evidence that HCC cell-derived exosomes may contribute to the establishment of a favorable microenvironment that supports cancer cell proliferation, invasion, and metastasis. These exosomes not only provide a versatile platform for diagnosis but also serve as a vehicle for drug delivery. In this paper, we review the role of exosomes involved in the proliferation, migration, and metastasis of HCC and describe their application in HCC diagnosis and treatment. We also discuss the prospects of exosome application in HCC and the research challenges.

【 授权许可】

CC BY   
© The Feinstein Institute for Medical Research 2023

【 图 表 】

Fig. 2