Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study

European Review of Aging and Physical Activity

Research Article

Rannveig S. Eldholm¹  Stian Lydersen²  Tom I. L. Nilsen³  Maren Lerfald⁴  Linda Ernstsen⁴  Nicolas Martinez-Velilla⁵  Ekaterina Zotcheva⁶  Geir Selbæk⁷ 

[1] Department of Geriatrics, Clinic of Medicine, St.Olavs Hospital, Trondheim, Norway;Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Trondheim, Norway;Department of Mental Health, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Trondheim, Norway;Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, PO box 8950, N-7491, Trondheim, Norway;Clinic of Anaesthesia and Intensive Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway;Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, PO box 8950, N-7491, Trondheim, Norway;Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway;Navarrabiomed, Hospital Universitario de Navarra, UPNA, IdiSNA, Pamplona, Spain;Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Oslo, Norway;Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Oslo, Norway;Faculty of Medicine, University of Oslo, Oslo, Norway;Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway;

关键词: Physical activity;    Blood pressure;    Trajectories;    Dementia;   

DOI  :  10.1186/s11556-023-00328-1

 received in 2023-06-09, accepted in 2023-09-21,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThere is lack of research on combinations of possible modifiable risk factors for dementia in a life-time perspective. Dementia has currently no cure, and therefore new knowledge of preventive factors is important. The purpose of this study is to investigate if changes in physical activity (PA) in combinations with systolic blood pressure (SBP) trajectories in mid to late life are related to development of dementia in older age.MethodsThis prospective cohort study uses data from four consecutive surveys of the HUNT Study, Norway. Dementia was assessed in the HUNT4 70 + sub-study (2017–19). Group-based trajectory modelling identified three SBP trajectories from HUNT1 (1984–86) to HUNT3 (2006–2008): low, middle, and high. Change in PA was categorized into four groups based on high or low PA level at HUNT1 and HUNT3 and were combined with the SBP trajectories resulting in 12 distinct categories. Logistic regression was used to estimate odds ratios (ORs) of dementia.ResultsA total of 8487 participants (55% women, mean age (SD) 44.8 (6.5) years at HUNT1) were included. At HUNT4 70 + , 15.2% had dementia. We observed an overall decrease in OR of dementia across the PA/SBP categories when ranked from low to high PA (OR, 0.96; 95% CI, 0.93 to 1.00, P = 0.04). Within PA groups, a low SBP trajectory was associated with lower OR for dementia, apart from those with decreasing PA. The strongest association was observed for people with stable high PA and low SBP trajectory (OR, 0.38; 95% confidence interval (CI), 0.13 to 1.10 and adjusted risk difference, -8.34 percentage points; 95% CI, -15.32 to -1.36).ConclusionOur findings illustrate the clinical importance of PA and SBP for dementia prevention and that favorable levels of both are associated with reduced occurrence of dementia.

【 授权许可】

CC BY   
© European Group for Research into Elderly and Physical Activity (EGRIPA) 2023

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