AGTR1 rs3772622 gene polymorphism increase the risk of nonalcoholic fatty liver disease patients suffer coronary artery disease in Northern Chinese Han population

Lipids in Health and Disease

Research

De-Xi Yuan¹  Ning Geng²  Yang Liu³  Yong-Ning Xin⁴  Shi-Ying Xuan⁴  Lin-Lin Lu⁵ 

[1] Department of Anorecta, Qilu Hospital, of Shandong University, Qingdao, China;Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, 266021, Qingdao, China;Department of Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China;Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, 266021, Qingdao, China;Department of Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China;Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, 266021, Qingdao, China;Digestive Disease Key Laboratory of Qingdao, Qingdao, Shandong Province, China;Digestive Disease Key Laboratory of Qingdao, Qingdao, Shandong Province, China;Central Laboratories, Qingdao Municipal Hospital, Qingdao, Shandong Province, China;

关键词: AGTR1;    Polymorphism;    Genetic;    Non-alcoholic Fatty Liver Disease;    Coronary Artery Disease;   

DOI  :  10.1186/s12944-016-0279-3

 received in 2016-04-16, accepted in 2016-06-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundCardiovascular disease (CAD) responsible and nonalcoholic fatty liver disease (NAFLD) are both metabolic diseases, and they are mostly influenced by genetic factors. The aim of our study is to evaluate the relationship between angiotensin II type-1 receptor (AGTR1) gene rs3772622 polymorphisms and the risk of developing coronary artery disease (CAD) in Chinese patients with NAFLD.MethodsGenotype for AGTR1 rs3772622 in 574 NAFLD patients with CAD or 589 NAFLD patients without CAD, 332 CAD patients exclude NAFLD and 338 health control subjects were determined by sequencing and polymerase chain reaction analysis. Relevant statistical methods were employed to analyze the genotypes, alleles and the clinical date. Inter-group differences and associations were assessed statistically using t-tests and Chi square and logistic analyses. The relative risk of AGTR1 rs3772622 for NAFLD was estimated by logistic regression analysis.ResultsNo significant difference in genotype and allele frequency of AGTR1 rs3772622 was found between the NAFLD without CAD population and the controls (P > 0.05). However, makeable difference was found when compared the CAD in patients with NAFLD and CAD free NAFLD patients (P < 0.001 OR = 2.09). Similarly, significant difference was found in AGTR1 rs3772622 genotype distribution between the groups of CAD patients and control (P = 0.046 OR = 1.71).ConclusionsAGTR1 rs3772622 gene polymorphism was not associated with the risk of NAFLD, but could increase the risk of NAFLD patients suffering from CAD in the Chinese Han population. Deeply mechanisms underlying the association between AGTR1 rs3772622 gene polymorphism and the risk of CAD in NAFLD patients need more research.

【 授权许可】

CC BY   
© The Author(s). 2016