Mortality and health-related quality of life in prevalent dialysis patients: Comparison between 12-items and 36-items short-form health survey

Health and Quality of Life Outcomes

Research

Tone Brit Hortemo Østhus¹  Ingrid Os¹  Valjbona Tiric Preljevic²  Toril Dammen²  Leiv Sandvik³  Torbjørn Leivestad⁴  Inger Hilde Nordhus⁵ 

[1] Department of Nephrology, Oslo University Hospital Ullevål, Kirkeveien 166, 0407, Oslo, Norway;Faculty of Medicine, University of Oslo, Oslo, Norway;Faculty of Medicine, University of Oslo, Oslo, Norway;Department of Psychiatry, Oslo, Norway;Faculty of Medicine, University of Oslo, Oslo, Norway;Section of Epidemiology and Statistics, Oslo University Hospital Ullevål, Oslo, Norway;Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway;Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway;Department of Clinical Psychology Faculty of Psychology, University of Bergen, Bergen, Norway;

关键词: Chronic kidney disease;    Dialysis;    Health-related quality of life;    Mortality;    Physical component summary score;    SF-12 and SF-36;   

DOI  :  10.1186/1477-7525-10-46

 received in 2012-01-12, accepted in 2012-05-06,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundTo assess health- related quality of life (HRQOL) with SF-12 and SF-36 and compare their abilities to predict mortality in chronic dialysis patients, after adjusting for traditional risk factors.MethodsThe Short-Form Health Survey (SF-36) with the embedded SF-12 was applied in 301 dialysis patients cross-sectionally. Physical and mental component summary (PCS-36, MCS-36, PCS-12, and MCS-12) scores were calculated. Clinical and demographic data were collected. Mortality (followed for up to 4.5 years) was analyzed with Kaplan Meier plots and Cox proportional hazards, after censoring for renal transplantation. Exclusion factors were observation time <2 months (n = 21) and missing component summary scores (n = 10 for SF-36; n = 28 for SF-12), thus 252 patient were included in the analyses.ResultsIn 252 patients (60.2 ± 15.5 years, 65.9% males, dialysis vintage 9.0, IQR 5.0-23.0 months), mortality during follow-up was 33.7%.(85 deaths). Significant correlations were observed between PCS-36 and PCS-12 (ρ = 0.93, p < 0.001) and between MCS-36 and MCS-12 (ρ = 0.95, p < 0.001). Mortality rate was highest in patients in the lowest quartile of PCS-12 (χ2 = 15.3, p = 0.002) and PCS-36 (χ2 = 16.7, p = 0.001). MCS was not associated with mortality. Adjusted hazard ratios for mortality were 2.5 (95% CI 1.0-6.3, PCS-12) and 2.7 (1.1 – 6.4, PCS-36) for the lowest compared with the highest (“best perceived”) quartile of PCS.ConclusionCompromised HRQOL is an independent predictor of poor outcome in dialysis patients. The SF-12 provided similar predictions of mortality as SF-36, and may serve as an applicable clinical tool because it requires less time to complete.

【 授权许可】

CC BY   
© Østhus et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.