Respiratory Research | |
Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score – a multicenter study | |
Research | |
Kaid Darwiche1  Filiz Oezkan2  Rainer Grobholz3  Malcolm Kohler4  Matthias Diebold4  Selma Hottinger4  Daniel P. Franzen4  Sarah R. Haile5  Alex Soltermann6  Wolfram Jochum7  Paul Komminoth8  Lukas Bubendorf9  Dirk Theegarten1,10  Sabina Berezowska1,11  | |
[1] Department of Interventional Pulmonology, Ruhrlandklinik, University Hospital Essen, Essen, Germany;Department of Interventional Pulmonology, Ruhrlandklinik, University Hospital Essen, Essen, Germany;James Thoracic Oncology Center, Ohio State University, Columbus, OH, USA;Department of Pathology, Cantonal Hospital Aarau, Aarau, Switzerland;Department of Pulmonology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland;Institute of Epidemiology, Biostatistics and Prevention, University of Zurich, Zurich, Switzerland;Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland;Institute of Pathology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland;Institute of Pathology, Triemli City Hospital, Zurich, Switzerland;Institute of Pathology, University Hospital Basel, Basel, Switzerland;Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;Institute of Pathology, University of Bern, Bern, Switzerland; | |
关键词: Solitary fibrous tumor; Pleura; MIB-1 proliferation index; Outcome; Score; | |
DOI : 10.1186/s12931-017-0693-8 | |
received in 2017-08-23, accepted in 2017-12-04, 发布年份 2017 | |
来源: Springer | |
【 摘 要 】
BackgroundAlthough the majority of solitary fibrous tumors of the pleura (SFTP) follow a benign course, 10–25% of patients suffer from recurrence or metastatic disease. Several scoring models have been proposed to predict the outcome. However, none of these included immunohistochemical (IHC) markers as possible prognosticators.MethodsIn this multicenter study, we collected clinical data and formalin-fixed and paraffin-embedded (FFPE) tissue blocks of patients with histologically proven SFTP which had been surgically resected between 2000 und 2015. After systematic and extensive IHC staining on tissue microarrays, the results were analyzed and compared to histomorphological and clinical data for their possible prognostic value.ResultsIn total, 78 patients (mean age 61 ± 11 years) were included. Of these, 9 patients (11%) had an adverse outcome including SFTP recurrence (n = 6) or SFTP-related death (n = 3). Mean overall survival was 172 ± 13 months. 1 and 10-year event-free survival rates were 99% and 93%. In the multivariable analysis only MIB-1 proliferation index (Ki-67) ≥10% (HR 12.3, CI 1.1–139.5, p = 0.043), ≥4 mitoses per 10 high power fields (HR 36.5, CI 1.2–1103.7, p = 0.039) and tumor size larger than 10 cm (HR 81.8, CI 1.7–4016.8, p = 0.027) were independently associated with adverse outcome.ConclusionA high proliferation rate by MIB-1 IHC was associated with impaired outcome. Upon this, we established a new score using mitosis, necrosis, size of the tumor and MIB-1, which performed better than the traditional scores in our data set. This prognostic score could help to better evaluate outcome of SFTP, but requires external validation.
【 授权许可】
CC BY
© The Author(s). 2017
【 预 览 】
Files | Size | Format | View |
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RO202311107653265ZK.pdf | 495KB | download |
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