Dynamics in multiplicity of Plasmodium falciparum infection among children with asymptomatic malaria in central Ghana

BMC Genetics

Research Article

Kwaku Poku Asante¹  David Dosoo¹  George Adjei¹  Seth Owusu-Agyei¹  Akua Kyerewaa Botwe²  Samuel Assafuah³ 

[1] Ghana Health Service. Health Research Unit, Kintampo Health Research Centre. MOH/GHS, P.O.Box 200, College of Health Street, Kintampo, Brong Ahafo, Ghana;Ghana Health Service. Health Research Unit, Kintampo Health Research Centre. MOH/GHS, P.O.Box 200, College of Health Street, Kintampo, Brong Ahafo, Ghana;Department of Medicine, Solna, Karolinska Institutet, 17176, Stockholm, Sverige, Sweden;Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;

关键词: Asymptomatic;    Falciparum;    Malaria;    MOI;    Children;    Kintampo;    Ghana;   

DOI  :  10.1186/s12863-017-0536-0

 received in 2016-07-30, accepted in 2017-07-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe determinants of malaria parasite virulence is not entirely known, but the outcome of malaria infection (asymptomatic or symptomatic) has been associated with carriage of distinct parasite genotypes. Alleles considered important for erythrocyte invasion and selected as candidate targets for malaria vaccine development are increasingly being shown to have distinct characteristics in infection outcomes. Any unique/distinct patterns or alleles linked to infection outcome should be reproducible for a given malaria-cohort regardless of location, time or intervention. This study compared merozoite surface protein 2 (MSP2) genotypes from children with asymptomatic malaria at same geographical location, from two time periods.ResultsAs the prevalence and incidence of malaria (measured for other studies) significantly reduced between 2004 (time point one) and 2009 (time point two), MSP2 multiplicity of infections (MOI) also reduced significantly from 2.3 at time point (TP) one to 1.9 at TP two. IC/3D7 genotypes out-numbered FC27 genotypes at both time points. At TP2 however, FC27 allele diversity was more than the IC/3D7 allele diversity. A decrease in the IC/3D7:FC27 genotype proportions from 2:1 at TP1 to 1:1 at TP2, seemed to be driven mainly by a decrease in carriage of IC/3D7 alleles. MOI was higher in the dry season than in the subsequent wet season, but the decrease was not significant at TP2.ConclusionMSP2 MOI was higher in the dry season than in the subsequent wet season, while the carriage of IC/3D7 alleles decreased over this time period. It may be that decreases in transmission are related specifically to the IC/3D7 allelic family. The influence of transmission on MSP2 allele diversity needs to be clearly deciphered in studies which should include the use of sensitive methods for the detection of polymorphic parasite markers for both symptomatic and asymptomatic malaria. Such studies will enable better understanding of associations between allelic variants, MOI, transmission, malaria infection and disease.

【 授权许可】

CC BY   
© The Author(s). 2017