Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

Malaria Journal

Review

Lauren Gong¹  Philip J Rosenthal²  Bryan Greenhouse²  Sunil Parikh³ 

[1] University of California Berkeley, University of California San Francisco Joint Medical Program, Berkeley, CA, USA;University of California, Box 1234, 94143, San Francisco, CA, USA;Yale University, New Haven, CT, USA;

关键词: Malaria;    Plasmodium falciparum;    Sickle cell trait;    Genetics;    Red blood cell polymorphisms;    Sickle haemoglobin;    Immunology;    Immunopathogenesis;    Protection;   

DOI  :  10.1186/1475-2875-12-317

 received in 2013-04-09, accepted in 2013-08-31,  发布年份 2013

来源: Springer

【 摘 要 】

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been proposed, and it is likely that multiple complex mechanisms are responsible for the observed protection. Increased evidence for an immune component of protection as well as novel mechanisms, such as enhanced tolerance to disease mediated by HO-1 and reduced parasitic growth due to translocation of host micro-RNA into the parasite, have recently been described. A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria.

【 授权许可】

Unknown   
© Gong et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.