Estimating canine cancer incidence: findings from a population-based tumour registry in northwestern Italy

BMC Veterinary Research

Research Article

Mauro Leschiera¹  Maria Claudia Vincenti²  Silvia Bertolini³  Cristiana Maurella³  Elisa Baioni³  Giuseppe Ru³  Rosanna Desiato³  Eugenio Scanziani⁴  Marzia Pezzolato⁵  Elena Bozzetta⁵ 

[1] Azienda Sanitaria Locale TO4, Ivrea, Turin, Italy;Azienda Sanitaria Locale Valle d’Aosta, Aosta, Italy;Biostatistics, Epidemiology and Risk Analysis Unit, Istituto Zooprofillattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Via Bologna 148, 10154, Torino, Italy;Department of Veterinary Science and Veterinary Public Health, Università degli Studi di Milano, Milan, Italy;Histopathology Unit, Istituto Zooprofillattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy;

关键词: Population-based cancer registry;    Dog;    Incidence;    Tumours;    Cancer epidemiology;    Sentinel animal;   

DOI  :  10.1186/s12917-017-1126-0

 received in 2017-01-11, accepted in 2017-06-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCanine cancer registry data can be put to good use in epidemiological studies. Quantitative comparison of tumour types may reveal unusual cancer frequencies, providing directions for research and generation of hypotheses of cancer causation in a specific area, and suggest leads for identifying risk factors. Here we report canine cancer incidence rates calculated from a population-based registry in an area without any known specific environmental hazard.ResultsIn its 90 months of operation from 2001 to 2008 (the observation period in this study), the population-based Piedmont Canine Cancer Registry collected data on 1175 tumours confirmed by histopathological diagnosis. The incidence rate was 804 per 100,000 dog-years for malignant tumours and 897 per 100,000 dog-years for benign tumours. Higher rates for all cancers were observed in purebred dogs, particularly in Yorkshire terrier and Boxer. The most prevalent malignant neoplasms were cutaneous mastocytoma and hemangiopericytoma, and mammary gland complex carcinoma and simplex carcinoma.ConclusionsThe Piedmont canine cancer registry is one of few of its kind whose operations have been consistently supported by long-term public funding. The registry-based cancer incidence rates were estimated with particular attention to the validity of data collection, thus minimizing the potential for bias. The findings on cancer incidence rates may provide a reliable reference for comparison studies. Researches conducted on dogs, used as sentinels for community exposure to environmental carcinogens, can be useful to detect excess risks in the incidence of malignant tumours in the human population.

【 授权许可】

CC BY   
© The Author(s). 2017