Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial

Nutrition Journal

Research

David J. Humphries¹  Kirsty E. Kliem¹  Alistair S. Grandison²  Colette C. Fagan²  Susan Todd³  Dafni Vasilopoulou⁴  Kim G. Jackson⁴  Julie A. Lovegrove⁵  Oonagh Markey⁶  David I. Givens⁷  Laura Y. Wang⁸  Keith Summerhill⁸  Albert Koulman⁹ 

[1] Animal, Dairy and Food Chain Sciences, University of Reading, RG6 6AP, Reading, UK;Department of Food and Nutritional Sciences, University of Reading, RG6 6AP, Reading, UK;Department of Mathematics and Statistics, School of Mathematical, Physical and Computational Sciences, University of Reading, RG6 6AX, Reading, UK;Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, RG6 6AP, Reading, UK;Department of Food and Nutritional Sciences, University of Reading, RG6 6AP, Reading, UK;Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, RG6 6AP, Reading, UK;Department of Food and Nutritional Sciences, University of Reading, RG6 6AP, Reading, UK;Institute for Food, Nutrition and Health, University of Reading, RG6 6AR, Reading, UK;Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, RG6 6AP, Reading, UK;Department of Food and Nutritional Sciences, University of Reading, RG6 6AP, Reading, UK;Present address: School of Sport, Exercise and Health Sciences, Loughborough University, LE11 3TU, Loughborough, UK;Institute for Food, Nutrition and Health, University of Reading, RG6 6AR, Reading, UK;MRC Elsie Widdowson Laboratory, 120 Fulbourn Road, CB1 9NL, Cambridge, UK;MRC Elsie Widdowson Laboratory, 120 Fulbourn Road, CB1 9NL, Cambridge, UK;NIHR BRC Nutritional Biomarker Laboratory, University of Cambridge, CB2 0QQ, Cambridge, UK;

关键词: Cardiovascular disease;    Dairy products;    Dietary fat composition;    Food-exchange model;    Fatty acids;    Monounsaturated fatty acids;    Nutrition assessment;    Phospholipids;    Saturated fatty acids;   

DOI  :  10.1186/s12937-017-0249-2

 received in 2017-02-10, accepted in 2017-05-03,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status.MethodsIn a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA).ResultsFollowing the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet.ConclusionThe food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance.Trial registrationClinicalTrials.gov Identifier: NCT02089035, date 05-01-2014.

【 授权许可】

CC BY   
© The Author(s). 2017