Oxidized low density lipoprotein, stem cells, and atherosclerosis

Lipids in Health and Disease

Review

Hui Yang¹  Sheng-hua Zhou¹  Ahmed Salah Salem Mohamed¹ 

[1] Department of Cardiology, Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China;

关键词: Oxidized LDL;    Stem cells;    Atherosclerosis;    LOX-1;    Oxidative stress;   

DOI  :  10.1186/1476-511X-11-85

 received in 2012-05-10, accepted in 2012-06-16,  发布年份 2012

来源: Springer

【 摘 要 】

Oxidized low density lipoprotein (ox-LDL), a risk factor of atherosclerosis, facilitates the formation and vulnerability of atherosclerotic plaque, thus contributing to several clinical complications. Stem cells participate in vascular repair after damage and atherosclerosis is a process of inflammation accompanied with vascular injury. Researchers have proposed that stem cells participate in the formation of atherosclerotic plaque. Also, because ox-LDL is capable of inducing toxic effects on stem cells, it is reasonable to postulate that ox-LDL promotes the progress of atherosclerosis via acting on stem cells. In the present article, we review the relationship between ox-LDL, stem cells, and atherosclerosis and a portion of the associated mechanisms.

【 授权许可】

Unknown   
© Yang et al.;licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.