Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status

BMC Infectious Diseases

Research Article

Abdellah Elhabazi¹  Lahcen Wakrim²  Sayeh Ezzikouri³  Soumaya Benjelloun³  Hajar Chihab⁴ 

[1] Cell Biology Department, Faculty of Sciences, Chouaib Doukkali University, El-Jadida, Morocco;Virology Unit, Immunovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco;Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place Louis Pasteur, 20360, Casablanca, Morocco;Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place Louis Pasteur, 20360, Casablanca, Morocco;Cell Biology Department, Faculty of Sciences, Chouaib Doukkali University, El-Jadida, Morocco;

关键词: Hepatitis B virus;    Functional receptor;    NTCP;    Polymorphism;   

DOI  :  10.1186/s12879-017-2214-2

 received in 2016-07-15, accepted in 2017-01-20,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV). The objective of this study was to determine if there was an association of the Ser267Phe variant (rs2296651) with HBV infection status in Moroccan patients.MethodsUsing a TaqMan 5’ allelic discrimination assay, the Ser267Phe variant was genotyped in 286 chronic hepatitis B patients, 135 individuals with spontaneous clearance from HBV infection and 109 healthy controls negative for hepatitis B serological markers.ResultsIn this cohort, we detected only wild-type genotype (S267S) in all groups. This polymorphism was not associated with the HBV infection status in Moroccan patients.ConclusionsThe S267F variant is absent among Moroccans regardless of chronic HBV infection status.

【 授权许可】

CC BY   
© The Author(s). 2017