Associations of coffee consumption with markers of liver injury in the insulin resistance atherosclerosis study

BMC Gastroenterology

Research Article

A. D. Liese¹  J. C. Dickson²  A. J. Hanley³  C. Lorenzo⁴  L. E. Wagenknecht⁵  S. M. Watkins⁶  J. K. Stiles⁷  S. J. Hamren⁷  S. M. Haffner⁸ 

[1] Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA;Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada;Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada;Departments of Medicine and Dalla Lana School of Public Health, University of Toronto and Leadership Sinai Centre for Diabetes, Mt Sinai Hospital, University of Toronto, 150 College Street, Room 341, M5S 3E2, Toronto, ON, Canada;Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA;Division of Public Health Sciences, School of Medicine, Wake Forest University, Winston-Salem, NC, USA;Lipomics Technologies, West Sacramento, CA, USA;Singulex, Inc., Alameda, CA, USA;University of Texas Health Science Center, San Antonio, TX, USA;

关键词: Coffee;    Caffeine;    Decaffeinated;    Type 2 diabetes;    ALT;    AST;    NAFLD liver fat score;    Fetuin-A;    Liver enzymes;    Insulin resistance atherosclerosis study;   

DOI  :  10.1186/s12876-015-0321-3

 received in 2015-01-09, accepted in 2015-07-16,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundCoffee consumption has been associated with reduced risk of developing type 2 diabetes mellitus (T2DM) however, the mechanism for this association has yet to be elucidated. Non-alcoholic fatty liver disease (NAFLD) characterizes and predicts T2DM yet the relationship of coffee with this disorder remains unclear. Our aim was to investigate the associations of coffee with markers of liver injury in 1005 multi-ethnic, non-diabetic adults in the Insulin Resistance Atherosclerosis Study.MethodsDietary intake was assessed using a validated 114-item food frequency questionnaire. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and fetuin-A were determined in fasting blood samples and the validated NAFLD liver fat score was calculated. Multivariate linear regression assessed the contribution of coffee to variation in markers of liver injury.ResultsCaffeinated coffee showed significant inverse associations with ALT (β = −0.08, p = 0.0111), AST (β = −0.05, p = 0.0155) and NAFLD liver fat score (β = −0.05, p = 0.0293) but not with fetuin-A (β = 0.04, p = 0.17). When the highest alcohol consumers were excluded, these associations remained (ALT β = −0.11, p = 0.0037; AST β = −0.05, p = 0.0330; NAFLD liver fat score β = −0.06, p = 0.0298). With additional adjustment for insulin sensitivity, the relationship with ALT remained significant (ALT β = −0.08, p = 0.0400; AST β = −0.03, p = 0.20; NAFLD liver fat score β = −0.03, p = 0.27). There were no significant associations of decaffeinated coffee with liver markers.ConclusionsThese analyses indicate a beneficial impact of caffeinated coffee on liver morphology and/or function, and suggest that this relationship may mediate the well-established inverse association of coffee with risk of T2DM.

【 授权许可】

Unknown   
© Dickson et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.