Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS)

Reproductive Biology and Endocrinology

Research

Andrea Weghofer¹  Norbert Gleicher²  David H Barad³ 

[1] Center for Human Reproduction (CHR) - New York and the Foundation for Reproductive Medicine, New York, NY, USA;Department of Obstetrics and Gynecology, Vienna University School of Medicine, Vienna, Austria;Center for Human Reproduction (CHR) - New York and the Foundation for Reproductive Medicine, New York, NY, USA;Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA;Center for Human Reproduction (CHR) - New York and the Foundation for Reproductive Medicine, New York, NY, USA;Departments of Epidemiology and Social Medicine and Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA;

关键词: Follicle Stimulate Hormone;    Ovarian Reserve;    Miscarriage Rate;    Preimplantation Genetic Screening;    Diminish Ovarian Reserve;   

DOI  :  10.1186/1477-7827-8-140

 received in 2010-10-01, accepted in 2010-11-10,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundDehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances in women with diminished ovarian reserve (DOR), and to reduce miscarriage rates by 50-80%. Such an effect is mathematically inconceivable without beneficial effects on embryo ploidy. This study, therefore, assesses effects of DHEA on embryo aneuploidy.MethodsIn a 1:2, matched case control study 22 consecutive women with DOR, supplemented with DHEA, underwent preimplantation genetic screening (PGS) of embryos during in vitro fertilization (IVF) cycles. Each was matched by patient age and time period of IVF with two control IVF cycles without DHEA supplementation (n = 44). PGS was performed for chromosomes X, Y, 13, 16, 18, 21 and 22, and involved determination of numbers and percentages of aneuploid embryos.ResultsDHEA supplementation to a significant degree reduced number (P = 0.029) and percentages (P < 0.001) of aneuploid embryos, adjusted for relevant covariates. Short term supplementation (4-12 weeks) resulted in greatest reduction in aneuploidy (21.6%, 95% CI -2.871-46.031).DiscussionBeneficial DHEA effects on DOR patients, at least partially, are the likely consequence of lower embryo aneuploidy. DHEA supplementation also deserves investigation in older fertile women, attempting to conceive, where a similar effect, potentially, could positively affect public health.

【 授权许可】

CC BY   
© Gleicher et al; licensee BioMed Central Ltd. 2010