Can egg donor selection be improved? - a pilot study

Reproductive Biology and Endocrinology

Methodology

Andrea Weghofer¹  Norbert Gleicher²  David H Barad³ 

[1] Center for Human Reproduction (CHR) - New York and Foundation for Reproductive Medicine, NY, USA;Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria;Center for Human Reproduction (CHR) - New York and Foundation for Reproductive Medicine, NY, USA;Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA;Center for Human Reproduction (CHR) - New York and Foundation for Reproductive Medicine, NY, USA;Departments of Epidemiology and Social Medicine as well as Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA;

关键词: Follicle Stimulate Hormone;    Ovarian Reserve;    FMR1 Gene;    Follicle Stimulate Hormone Level;    Donor Selection;   

DOI  :  10.1186/1477-7827-8-76

 received in 2010-03-12, accepted in 2010-06-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAccurate assessments of ovarian reserve (OR) in egg donor candidates are crucial for maximal donor selection. This study assesses whether recently reported new methods of OR assessment by age-specific (as-), rather than non-as (nas-) hormones, follicle stimulating hormone (FSH) and anti-Müllerian hormone (AMH), and triple nucleotide (CGG) repeats on the FMR1 (fragile X) gene have the potential of improving egg donor selection.MethodsSeventy-three consecutive egg donor candidates (candidates), amongst those 21 who reached egg retrieval (donors), were prospectively investigated for as-FSH, as-AMH and number of CGG repeats. Abnormal findings were assessed in candidates and donors and oocyte yields in the latter were statistically associated with abnormal FSH and AMH (>/< 95% CI of as-levels) and with normal/abnormal numbers of CGG repeats (normal range 26-32).ResultsAmongst candidates mean as-AMH was 3.8 +/- 2.8 ng/mL (37.0% normal, 3.0 +/- 0.7 ng/mL; 26.6% low, 1.5 +/- 0.5 ng/mL; and 37.0% high, 5.8 +/- 2.2 ng/mL). AMH among donors was 4.2 +/- 1.7 ng/mL (33.3% normal, 14.3% low, and 52.4% high), yielding 17.8 +/- 7.2 oocytes, 42.9% in normal range (10-15), 9.5% in low (less than or equal to 9) and 47.6.% in high range (16-32). Candidates in 41.9% and donors in 38.1% demonstrated normal CGG counts; the remained were mostly heterozygous abnormal.DiscussionProspective assessment of even carefully prescreened candidates and donors still demonstrates shortcomings on both ends of the OR spectrum. Utilization of ovarian reserve testing methods, like as-hormones and CGG repeats on the FMR1 gene have potential of improving candidate selections.

【 授权许可】

CC BY   
© Gleicher et al; licensee BioMed Central Ltd. 2010