期刊论文详细信息
Lipids in Health and Disease
Obesity indices and inflammatory markers in obese non-diabetic normo- and hypertensive patients: a comparative pilot study
Research
Maciej Banach1  Marek Paradowski2  Rafał N Wlazeł2  Jacek Rysz3  Mariusz Stępień3  Anna Stępień3 
[1] Department of Hypertension, Medical University of Lodz, Lodz, Poland;Department of Laboratory Diagnostics and Clinical Biochemistry, Medical University of Lodz, Lodz, Poland;Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Żeromskiego str. 113, 90-549, Lodz, Poland;
关键词: Obesity;    Hypertension;    Chronic inflammation;    Obesity indices;   
DOI  :  10.1186/1476-511X-13-29
 received in 2014-01-23, accepted in 2014-02-05,  发布年份 2014
来源: Springer
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【 摘 要 】

BackgroundThe aim of this study was to estimate associations between inflammatory markers and obesity indices in normo- and hypertensive subjects.Methods65 obese adult subjects were divided into two groups: (A) of hypertensives (n = 54) and (B) of normotensives (n = 11). Waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), visceral adiposity index (VAI), body adiposity index (BAI) and tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and high sensitivity C-reactive protein (hsCRP) serum concentrations were estimated.ResultsIn group A WHtR was higher (0.69 ± 0.07 vs 0.63 ± 0.06; p < 0.01), hsCRP correlated with BMI and WHtR (r = 0.343; p = 0.011 and r = 0.363; p < 0.01, respectively). BAI correlated with hsCRP in group A and B (r = 0.329; p < 0.05 and r = 0.642; p < 0.05; respectively) and in females and males (r = 0.305; p = 0.05 and r = 0.44; p < 0.05, respectively). In females hsCRP was higher (3.2 ± 2.2 mg/l vs 2.1 ± 1.5 mg/l; p < 0.05). In patients without lipid lowering treatment hsCRP and IL-6 were higher (3.2 ± 1.7 mg/l vs 2.4 ±2.2 mg/l; p = 0.01 and 15.9 ± 7.2 pg/ml vs 13.6 ± 9.9 pg/ml; p < 0.01, respectively).ConclusionsWHtR is a sensitive index associated with chronic inflammation in obese hypertensive subjects. BAI correlates with hsCRP independently of hypertension and sex. hsCRP is more sensitive marker associated with obesity than IL-6 and TNF-α. Lipid lowering treatment influence chronic inflammation.

【 授权许可】

CC BY   
© Stępień et al.; licensee BioMed Central Ltd. 2014

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