The association between blood glucose and oxidized lipoprotein(a) in healthy young women

Lipids in Health and Disease

Short Paper

Shingo Yamada¹  Toshiyuki Yamada²  Shuumarjav Uurtuya²  Kazuhiko Kotani²  Nobuyuki Taniguchi²  Ikunosuke Sakurabayashi³ 

[1] Central Research Institute, Shino-Test Corporation, Kanagawa, Japan;Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan;Saitama Memorial Hospital, Saitama, Japan;

关键词: Blood Glucose Concentration;    ELISA System;    Increase Blood Glucose;    Healthy Young Woman;    Normal Glucose Level;   

DOI  :  10.1186/1476-511X-9-103

 received in 2010-05-25, accepted in 2010-09-21,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundOxidized lipoproteins play important roles in the atherosclerotic processes. Oxidized lipoprotein(a) (oxLp(a)) may be more potent in atherosclerotic pathophysiology than native Lp(a), a cardiovascular disease-relevant lipoprotein. Increased blood glucose concentrations can induce oxidative modification of lipoproteins. The aim of this study was to investigate the association between circulating oxLp(a) and cardiometabolic variables including blood glucose in healthy volunteers within the normal range of blood glucose.MethodsSeveral cardiometabolic variables and serum oxLp(a) (using an ELISA system) were measured among 70 healthy females (mean age, 22 years).ResultsLp(a) and glucose were significantly and positively correlated with oxLp(a) in simple correlation test. Furthermore, a multiple linear regression analysis showed oxLp(a) to have a weakly, but significantly positive and independent correlation with only blood glucose (β = 0.269, P < 0.05).ConclusionsThese results suggest that increased glucose may enhance the oxidization of Lp(a) even at normal glucose levels.

【 授权许可】

CC BY   
© Kotani et al; licensee BioMed Central Ltd. 2010