The Canadian HIV and aging cohort study - determinants of increased risk of cardio-vascular diseases in HIV-infected individuals: rationale and study protocol

BMC Infectious Diseases

Study Protocol

Marianne Harris¹  Petronela Ancuta²  Cécile L. Tremblay²  Jean-Pierre Routy³  Jean-Guy Baril⁴  Sylvie Trottier⁴  Benoit Trottier⁴  Michal Abrahamowicz⁵  Zhitong Zhu⁵  Carl Chartrand-Lefebvre⁶  Sharon Walmsley⁷  Brian Conway⁷  Alexander Wong⁸  Madeleine Durand⁹  Colin Kovacs^1,10  Christos Tsoukas^1,11  George Thanassoulis^1,12  Nicole Bernard^1,13  Kenneth Marc Monteith^1,14  Samer Mansour^1,14  Paul A. MacPherson^1,14 

[1] BC Centre for Excellence in HIV/AIDS, Vancouver, Canada;Centre de recherche du CHUM, Montreal, Canada;Chronic viral infection service and Division of Hematology, McGill University Health Centre, Montreal, Canada;Clinique médicale urbaine du Quartier latin, Montreal, Canada;Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada;Department of Radiology, Centre hospitalier de l’Université de Montréal, Montréal, Canada;Division of Infectious Diseases, University Health Network, Toronto, Canada;Infectious Diseases Clinic, Regina Qu’Appelle Health Region, Regina, Canada;Internal Medicine service, Centre de Recherche du CHUM, H2J 1T8, Montréal, QC, Canada;Maple Leaf Medical HIV Research Collaborative Inc., Toronto, Canada;McGill University, Immunology service, Montreal General Hospital, Montreal, Canada;Preventive and Genomic Cardiology, McGill University Health Center and Research Institute, Montreal, Canada;Research Institute of the McGill University Health Center, Division of Experimental Medicine, McGill University, Division of Clinical Immunology, McGill University health Center (MUHC), Chronic Viral Illness Service, Montreal, Canada;The Ottawa Hospital Research Institute and the University of Ottawa, Ottawa, Canada;

关键词: HIV;    Aging;    Cardiovascular;    Prospective cohort;    Study protocol;   

DOI  :  10.1186/s12879-017-2692-2

 received in 2017-06-20, accepted in 2017-08-17,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWith potent antiretroviral drugs, HIV infection is becoming a chronic disease. Emergence of comorbidities, particularly cardiovascular disease (CVD) has become a leading concern for patients living with the infection. We hypothesized that the chronic and persistent inflammation and immune activation associated with HIV disease leads to accelerated aging, characterized by CVD. This will translate into higher incidence rates of CVD in HIV infected participants, when compared to HIV negative participants, after adjustment for traditional CVD risk factors. When characterized further using cardiovascular imaging, biomarkers, immunological and genetic profiles, CVD associated with HIV will show different characteristics compared to CVD in HIV-negative individuals.Methods/designThe Canadian HIV and Aging cohort is a prospective, controlled cohort study funded by the Canadian Institutes of Health Research. It will recruit patients living with HIV who are aged 40 years or older or have lived with HIV for 15 years or more. A control population, frequency matched for age, sex, and smoking status, will be recruited from the general population. Patients will attend study visits at baseline, year 1, 2, 5 and 8. At each study visit, data on complete medical and pharmaceutical history will be captured, along with anthropometric measures, a complete physical examination, routine blood tests and electrocardiogram. Consenting participants will also contribute blood samples to a research biobank. The primary outcome is incidence of a composite of: myocardial infarction, coronary revascularization, stroke, hospitalization for angina or congestive heart failure, revascularization or amputation for peripheral artery disease, or cardiovascular death. Preplanned secondary outcomes are all-cause mortality, incidence of the metabolic syndrome, incidence of type 2 diabetes, incidence of renal failure, incidence of abnormal bone mineral density and body fat distribution. Patients participating to the cohort will be eligible to be enrolled in four pre-planned sub-studies of cardiovascular imaging, glucose metabolism, immunological and genetic risk profile.DiscussionThe Canadian HIV and Aging Cohort will provide insights on pathophysiological pathways leading to premature CVD for patients living with HIV.

【 授权许可】

CC BY   
© The Author(s). 2017