BMC Medicine | |
Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study | |
Linnea Sjöberg1  Laura Monica Pérez1  Davide L. Vetrano1  Federico Triolo1  Amaia Calderón-Larrañaga1  Alexander Darin-Mattsson1  Ingemar Kåreholt1  Shireen Sindi2  Miia Kivipelto2  Marco Inzitari3  | |
[1] Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University;Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet;REFiT Barcelona Research Group, Vall d’Hebrón Research Institute and Parc Sanitari Pere Virgili; | |
关键词: Sleep disturbances; Multimorbidity; Aging; Cardiovascular; Neuropsychiatric; Musculoskeletal; | |
DOI : 10.1186/s12916-020-01846-w | |
来源: DOAJ |
【 摘 要 】
Abstract Background Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults. Methods Data were gathered from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study of subjects aged 60+ (N = 3363). The study included a subsample (n = 1189) without multimorbidity at baseline (< 2 chronic diseases). Baseline sleep disturbances were derived from the Comprehensive Psychiatric Rating Scale and categorized as none, mild, and moderate–severe. The number of chronic conditions throughout the 9-year follow-up was obtained from clinical examinations. Linear mixed models were used to study the association between sleep disturbances and the speed of chronic disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, and psychotropic drug use. We repeated the analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases as the outcome. Results Moderate–severe sleep disturbances were associated with a higher speed of chronic disease accumulation (ß/year = 0.142, p = 0.008), regardless of potential confounders. Significant positive associations were also found between moderate–severe sleep disturbances and neuropsychiatric (ß/year = 0.041, p = 0.016) and musculoskeletal (ß/year = 0.038, p = 0.025) disease accumulation, but not with cardiovascular diseases. Results remained stable when participants with baseline dementia, cognitive impairment, or depression were excluded. Conclusion The finding that sleep disturbances are associated with faster chronic disease accumulation points towards the importance of early detection and treatment of sleep disturbances as a possible strategy to reduce chronic multimorbidity among older adults.
【 授权许可】
Unknown