Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes

Cardiovascular Diabetology

Original Investigation

Zhaoping Chen¹  Li Sheng¹  Fang Wang¹  Bingbing Cha¹  Jun Liu¹  Wenjie Cao² 

[1] Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, 801 Heqing Road, Shanghai, China;Department of Neurology, Huashan hospital, Shanghai medical college, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China;

关键词: Osteocalcin;    Intima-media thickness;    Carotid atherosclerotic plaques;    Atherosclerosis;   

DOI  :  10.1186/1475-2840-12-22

 received in 2012-12-18, accepted in 2013-01-19,  发布年份 2013

来源: Springer

【 摘 要 】

ObjectiveTo investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.MethodsWe performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.ResultsThe crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all P<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.ConclusionsSerum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.

【 授权许可】

Unknown   
© Sheng et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.