Ezetimibe/Simvastatin 10/20 mg versus Rosuvastatin 10 mg in high-risk hypercholesterolemic patients stratified by prior statin treatment potency

Lipids in Health and Disease

Research

Helena Vaverkova¹  Michel Farnier²  Margus Viigimaa³ 

[1] 3rd Department of Internal Medicine, Medical Faculty and University Hospital Olomouc, Olomouc, Czech Republic;Point Medical - Rond Point de la Nation, Dijon, France;Tallinn University of Technology, Technomedicum, Ehitajate St. 5, 19086, Tallinn, Estonia;

关键词: Statin;    Simvastatin;    Rosuvastatin;    Ezetimibe;    High Cardiovascular Risk;   

DOI  :  10.1186/1476-511X-9-127

 received in 2010-09-08, accepted in 2010-11-04,  发布年份 2010

来源: Springer

【 摘 要 】

ObjectiveThis post-hoc analysis compared the lipid-altering efficacy of Ezetimibe/Simvastatin 10/20 mg (EZ/Simva) versus Rosuvastatin 10 mg (Rosuva) in patients stratified by statin potency/dose prior to randomization.MethodsPatients with elevated low-density lipoprotein cholesterol (LDL-C) despite prior statin treatment (n = 618) were randomized 1:1 to EZ/Simva 10/20 mg or Rosuva 10 mg for 6 weeks. Percent change from baseline in lipids and attainment of lipid targets were assessed within each subgroup (low potency n = 369, high potency n = 249). Consistency of the treatment effect across subgroups was evaluated by testing for treatment-by-subgroup interaction. No multiplicity adjustments were made.ResultsSignificant treatment-by-subgroup interaction occurred for LDL-C (p = 0.013), total cholesterol (p = 0.025), non-HDL-C (p = 0.032), and apolipoprotein B (p = 0.016) with greater between-treatment differences in favor of EZ/Simva observed in patients from the high potency stratum vs low potency stratum. Individual and triple target attainment was higher for Eze/Simva compared with Rosuva in both strata.ConclusionsCompared with Rosuva, switching to EZ/Simva provided greater reductions in LDL-C, total cholesterol, non-HDL-C and apolipoprotein B and higher target attainment in patients on prior statin treatment, regardless of potency, although patients treated with higher potency statins prior to randomization experienced greater between treatment differences in favor of EZ/Simva.Trial RegistrationRegistered at ClinicalTrials.gov: NCT00479713

【 授权许可】

CC BY   
© Viigimaa et al; licensee BioMed Central Ltd. 2010