Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles

Lipids in Health and Disease

Hypothesis

Whitney P Bowe¹  Alan C Logan² 

[1] Department of Dermatology, State University of New York Downstate Medical Center, 11203, Brooklyn, New York, USA;Integrative Care Centre of Toronto, 3600 Ellesmere Road, Unit 4, ON M1C 4Y8, Toronto, Canada;

关键词: Acne;    Squalene;    Isotretinoin;    Benzoyl Peroxide;    Mental Health Disorder;   

DOI  :  10.1186/1476-511X-9-141

 received in 2010-12-04, accepted in 2010-12-09,  发布年份 2010

来源: Springer

【 摘 要 】

Acne vulgaris is a common dermatological disorder, one that is frequently associated with depression, anxiety and other psychological sequelae. In recent years there has been an increasing focus on the extent to which oxidative stress is involved in the pathophysiology of acne. Emerging studies have shown that patients with acne are under increased cutaneous and systemic oxidative stress. Indeed, there are indications that lipid peroxidation itself is a match that lights an inflammatory cascade in acne. The notion that lipid peroxidation is a 'starter gun' in acne is not a new one; here we review the nearly 50-year-old lipid peroxidation theory and provide a historical perspective to the contemporary investigations and clinical implications.In addition, we present a novel hypothesis in which lipid peroxidation may be priming an increased susceptibility to co-morbid depression and anxiety in those with acne. The emerging research on the systemic burden of oxidative stress in acne sheds further light on the brain-skin axis. The recent findings also suggest potential avenues of approach for the treatment of acne via specific nutrients, dietary modifications, oral and topical interventions.

【 授权许可】

CC BY   
© Bowe and Logan; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.