Stem cell membrane-coated isotretinoin for acne treatment

Journal of Nanobiotechnology

Yongri Jin¹  Shiyi Wang²  Rihua Jiang²  Mingji Zhu²  Tianqi Meng²  JeungHoon Lee³  Jing Li⁴  Jinlan Jiang⁴  Fuqiang Zhang⁴ 

[1] College of Chemistry, Jilin University, Changchun, Jilin, China;Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China;Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Republic of Korea;Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China;

关键词: Stem cell;    Acne;    Isotretinoin;    Transdermal;    Nanoparticles;   

DOI  :  10.1186/s12951-020-00664-9

来源: Springer

【 摘 要 】

BackgroundTopical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers with great curative effects, low side effects, and strong transdermal ability.ResultsIn a rabbit model of hyperkeratinization, STCM-ATRA-NPs showed significant therapeutic efficacy. By contrast, negative therapeutic efficacy was observed in a golden hamster model of hyper sebum production. Scanning electron microscopy and Fourier transform infrared spectral analyses showed that nanoparticles could penetrate the stratum corneum. Western blotting demonstrated that the nanoparticles could enhance the transdermal efficacy of isotretinoin by reducing the effect of keratin and tight junction proteins. Further, nanoparticles enhanced endocytosis, thereby promoting drug penetration and absorption into the skin.ConclusionSTCM-ATRA-NPs were demonstrated to control isotretinoin release, reducing its side effects, and efficiently permeating through the skin by reducing the effect of keratin and tight junction proteins and enhancing endocytosis.

【 授权许可】

CC BY