Target network differences between western drugs and Chinese herbal ingredients in treating cardiovascular disease

BMC Bioinformatics

Research

Yi Sun¹  Linlin Yang¹  Kailin Tang²  Li Ye³  Peng Fu⁴  Zhiwei Cao⁵ 

[1] School of Life Science and Technology, Tongji University, 200092, Shanghai, China;Shanghai Center for Bioinformation Technology, 201203, Shanghai, China;School of Life Science and Technology, Tongji University, 200092, Shanghai, China;State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, 200237, Shanghai, China;State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, 200237, Shanghai, China;Shanghai Center for Bioinformation Technology, 201203, Shanghai, China;State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, 200237, Shanghai, China;Shanghai Center for Bioinformation Technology, 201203, Shanghai, China;School of Life Science and Technology, Tongji University, 200092, Shanghai, China;

关键词: Chinese Herb;    Quinapril;    Vaccine Adjuvant;    Successful Target;    Disease Network;   

DOI  :  10.1186/1471-2105-15-S4-S3

来源: Springer

【 摘 要 】

BackgroundWestern drugs have achieved great successes in CVDs treatment. However, they may lead to some side effects and drug resistance. On the other hand, more and more studies found that Traditional Chinese herbs have efficient therapeutic effects for CVDs, while their therapeutic mechanism is still not very clear. It may be a good view towards molecules, targets and network to decipher whether difference exists between anti-CVD western drugs and Chinese herbal ingredients.ResultsAnti-CVD western drugs and Chinese herbal ingredients, as well as their targets were thoroughly collected in this work. The similarities and the differences between the herbal ingredients and the western drugs were deeply explored based on three target-based perspectives including biochemical property, regulated pathway and disease network. The biological function of herbal ingredients' targets is more complex than that of the western drugs' targets. The signal transduction and immune system associated signaling pathways, apoptosis associated pathways may be the most important pathway for herbal ingredients, however the western drugs incline to regulate vascular smooth muscle contraction associated pathways. Chinese herbal ingredients prefer to regulate the downstream proteins of apoptosis associated pathway; while the western drugs incline to regulate the upstream proteins of VECC (Vascular Epidermal Cells Contraction) related pathways.ConclusionIn summary, the characteristics identified in this study would be valuable for designing new network-based multi-target CVD drugs or vaccine adjuvants.

【 授权许可】

Unknown   
© Fu et al; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.