Pharmacodynamic Evaluation of 4 Angiotensin‐Converting Enzyme Inhibitors in Healthy Adult Horses

Journal of Veterinary Internal Medicine

T. Afonso¹  S. Giguère¹  G. Rapoport²  L.J. Berghaus¹  M.H. Barton¹ 

[1] Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA;Department of Small Animal Medicine and Surgery (Rapoport, Coleman), College of Veterinary Medicine, University of Georgia, Athens, GA

关键词: ACE inhibitor;    Benazepril;    Cardiology;    Equine;    Perindopril;    Quinapril;    Ramipril;   

DOI  :  10.1111/jvim.12153

来源: Wiley

【 摘 要 】

Abstract

Background

Angiotensin-converting enzyme (ACE) inhibitors are used in horses with cardiovascular disorders despite the paucity of available data regarding their efficacy.

Hypothesis

The degree of serum ACE inhibition varies considerably between drugs.

Animals

Eight healthy adult horses.

Methods

Randomized prospective study. Horses were fasted overnight prior to receiving one of 4 ACE inhibitors intragastrically, administered at one of 2 dosages, using a randomized Latin square design (benazepril: 0.5 and 0.25 mg/kg; ramipril: 0.3 and 0.1 mg/kg; quinapril: 0.25 and 0.125 mg/kg; perindopril: 0.1 and 0.05 mg/kg). Serum ACE activity was measured using a kinetic spectrophotometric method.

Results

There was a significant effect of drug and dosage on maximum ACE inhibition (I_max), ACE inhibition 24 hours after administration (I_24h), and area under the curve (AUC_0–48h). Benazepril at 0.5 mg/kg resulted in significantly higher I_max (86.9 ± 7.0%) and I_24h (60.3 ± 7.9%) compared to the other drugs. There was a significant decrease in indirect blood pressure (BP) over time after administration of each drug, but differences in BP were not significantly different between drugs. Pharmacodynamic variables measured after administration of benazepril to horses with free access to hay were not significantly different from those obtained after fasting. Administration of benazepril orally once daily for 7 days did not result in a cumulative effect on ACE inhibition.

Conclusions and Clinical Importance

Of the ACE inhibitors tested, oral benazepril (0.5 mg/kg) is the most effective at inhibiting serum ACE activity in healthy horses.

【 授权许可】

Unknown   
Copyright © 2013 by the American College of Veterinary Internal Medicine