Comparison of Efficacy of Long‐term Oral Treatment with Telmisartan and Benazepril in Cats with Chronic Kidney Disease

Journal of Veterinary Internal Medicine

U. Sent¹  R. Gössl¹  J. Elliott³  H. M. Syme² 

[1] Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany;Department of Clinical Sciences and Services, Royal Veterinary College, Herts, UK;Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK

关键词: ACE inhibitor;    Angiotensin II receptor blocker;    Benazepril;    Proteinuria;   

DOI  :  10.1111/jvim.13639

来源: Wiley

【 摘 要 】

Abstract

Background

The efficacy and benefits of telmisartan in cats with chronic kidney disease (CKD) have not previously been reported.

Hypothesis

Long-term treatment of cats with CKD using telmisartan decreases urine protein-to-creatinine ratio (UP/C) similar to benazepril.

Animals

Two-hundred and twenty-four client-owned adult cats with CKD.

Methods

Prospective, multicenter, controlled, randomized, parallel group, blinded clinical trial with noninferiority design. Cats were allocated in a 1 : 1 ratio to either telmisartan (1 mg/kg; n = 112) or benazepril (0.5–1.0 mg/kg; n = 112) PO q24 h. The primary endpoint was prospectively defined as the change in proteinuria (benazepril:telmisartan) based on a log transformed weighted average of UP/C change from baseline (AUC 0→t/t) as a percentage compared using a confidence interval (CI) approach. Changes of UP/C from baseline were assessed on all study days and corrected for multiple comparisons.

Results

Telmisartan proved noninferior to benazepril in controlling proteinuria (CI, −0.035 to 0.268). At Day 180, UP/C compared to baseline in the telmisartan group was significantly lower (−0.05 ± 0.31; P = .016), whereas in the benazepril group the change (−0.02 ± 0.48) was not statistically significant (P = .136). Similar results were obtained at all assessment points with significant decrease in UP/C occurring with telmisartan but not benazepril.

Conclusion and Clinical Importance

Both telmisartan and benazepril were well tolerated and safe. Telmisartan proved to be noninferior to benazepril and significantly decreased proteinuria relative to baseline at all assessment points whereas benazepril did not.

【 授权许可】

CC BY-NC   
Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

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