Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis

World Journal of Surgical Oncology

Research

Hideki Yamamoto¹  Kazuaki Tanabe¹  Takahisa Suzuki¹  Hideki Ohdan¹  Noriaki Tokumoto¹  Kazuhiro Yoshida² 

[1] Department of Surgery, Division of Frontier Medical Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan;Department of Surgical Oncology, Graduate School of Medicine, Gifu University, Gifu, Japan;

关键词: Gastric Cancer;    Overall Survival;    Neutropenia;    Docetaxel;    Febrile Neutropenia;   

DOI  :  10.1186/1477-7819-8-40

 received in 2010-03-02, accepted in 2010-05-19,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundWe performed a single-institution retrospective study to evaluate the efficacy and toxicities of combination therapy with docetaxel and S-1 in patients with advanced or recurrent gastric cancer.MethodsEighty-six patients with advanced or recurrent gastric cancer were enrolled. Patients received docetaxel, 40 mg/m2, on day 1 and oral S-1, 80 mg/m2/day, on days 1 to 14 every 3 weeks.ResultsAll 84 patients were assessable for response. The overall response rate was 52.4% (44/84) and the disease control rate was 96.4% (81/84). Median time to progression (TTP) and overall survival (OS) were 6.5 (95% CI, 4.8-8.1 months) and 15.1 months (95% CI, 11.7-18.5 months), respectively. The major toxicities were neutropenia, leukopenia, alopecia and anorexia. Grade 3 or 4 hematologic toxicities included neutropenia in 31 patients (36.0%), leukopenia in 27 (31.7%), febrile neutropenia in four (4.7%), and anemia in one (1.2%). Other grade 3 toxicities included anorexia in five patients (5.8%), and stomatitis, diarrhea and nausea in one each (1.2%). There was one treatment-related death (1.2%).ConclusionThe combination of docetaxel and S-1 had good clinical activity with acceptable toxicity in patients with advanced or recurrent gastric cancer.

【 授权许可】

CC BY   
© Tanabe et al; licensee BioMed Central Ltd. 2010