Survival in patients with stage IV noncardia gastric cancer - the influence of DNA ploidy and Helicobacter Pyloriinfection

BMC Cancer

Research Article

George Agrogiannis¹  Nikolaos Kavantzas¹  Efstratios S Patsouris¹  Emmanouil Pikoulis²  Ioannis Karavokyros²  John Griniatsos²  Christos Kosmas³  Stavros Sougioultzis⁴  John Syrios⁴  Ioannis D Xynos⁴  Nikolas Tsavaris⁴ 

[1] 1st Department of Pathology, Laikon General Hospital, Athens University School of Medicine, Athens, Greece;1st Department of Surgery, Laikon General Hospital, Athens University School of Medicine, Athens, Greece;2nd Department of Medical Oncology, Metaxa Cancer Hospital, Piraeus, Greece;Department of Pathophysiology, Oncology Unit, Laikon General Hospital, Athens University School of Medicine, Athens, Greece;

关键词: Gastric Cancer;    Overall Survival;    Liver Metastasis;    Gastric Cancer Patient;    Advanced Gastric Cancer;   

DOI  :  10.1186/1471-2407-12-264

 received in 2012-01-23, accepted in 2012-06-21,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPalliative surgery followed by postoperative chemotherapy is a challenging approach in the treatment of stage IV gastric cancer yet patients must be carefully selected on the basis of likely clinical benefit.MethodsThe records of 218 patients with histological diagnosis of gastric adenocarcinoma who underwent palliative surgery followed by postoperative chemotherapy were retrospectively reviewed. Twelve potential prognostic variables including tumour DNA index and serum IgG anti- Helicobacter pylori (HP) antibodies were evaluated for their influence on overall survival by multivariate analysis.ResultsThe median survival was 13.25 months [95% Confidence Interval (CI) 12.00, 14.50]. Three factors were found to have an independent effect on survival: performance status (PS) [PS 60–70 vs. 90–100 Hazard Ratio (HR) 1.676; CI 1.171-2.398, p = 0.005], liver metastases (HR 1.745; CI 1.318-2.310, p < 0.001), and DNA Index as assessed by Image cytometry (2.2-3.6 vs. >3.6 HR 3.059; CI 2.185-4.283, p < 0.001 and <2.2 vs. >3.6 HR; 4.207 CI 2.751-6.433 <0.001). HP infection had no statistically significant effect on survival by either univariate or multivariate analysis.ConclusionPoor pre-treatment PS, the presence of liver metastasis and high DNA Index were identified factors associated with adverse survival outcome in patients with Stage IV gastric cancer treated with palliative gastrectomy and postoperative chemotherapy. HP infection had no influence on survival of these patients.

【 授权许可】

Unknown   
© Syrios et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.