Field evaluation of the efficacy of Mycobacterium bovis BCG vaccine against tuberculosis in goats

BMC Veterinary Research

Research Article

Miriam Grasa¹  Claudia Arrieta-Villegas²  Irene Mercader³  Enric Vidal⁴  Bernat Pérez de Val⁴  Mariano Domingo⁵ 

[1] Associació de Ramaders de Cabrum de Catalunya, 25400, Les Borges Blanques, Lleida, Catalonia, Spain;Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Catalonia, Spain;Departament d’Agricultura, Ramaderia, Pesca i Alimentació de la Generalitat de Catalunya, 08007, Barcelona, Catalonia, Spain;IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Catalonia, Spain;IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Catalonia, Spain;Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Catalonia, Spain;

关键词: BCG;    Efficacy;    Field study;    Goats;    Tuberculosis;    Vaccine;   

DOI  :  10.1186/s12917-017-1182-5

 received in 2016-12-13, accepted in 2017-08-10,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundControl of animal tuberculosis (TB) through vaccination has emerged as a long-term strategy to complement test and slaughter control strategy. A pilot trial under field conditions was conducted in a goat herd with high TB prevalence to assess the efficacy of the Mycobacterium bovis BCG vaccine.ResultsTwenty-three goat kids vaccinated with BCG and other 22 unvaccinated control kids were euthanized at 18 months post-vaccination. Gross pathological and histopathological examination of target tissues was performed for detection of tuberculous lesions and assessment of vaccine efficacy. Mycobacterial culture and DNA detection were used to confirm Mycobacterium caprae infection. Vaccination significantly reduced the number of animals with TB lesions compared to unvaccinated controls (35% and 77%, respectively; P < 0.01). This reduction was even higher if only extra-pulmonary infection was considered (17% and 68%, respectively; P < 0.001).ConclusionsThis trial demonstrates that BCG vaccination of goats can significantly reduce the TB lesion rates in high disease exposure conditions, indicating that vaccination could contribute to the control of TB in domestic goats.

【 授权许可】

CC BY   
© The Author(s). 2017