Ions doped melanin nanoparticle as a multiple imaging agent

Journal of Nanobiotechnology

Research

Kwan Soo Hong¹  Moon-Sun Jang²  Jung Hee Lee²  Shin-Woo Ha³  Young Il Yoon³  Emmanuel Hui⁴  Hee-Sang Cho⁵  Tae-Jong Yoon⁶ 

[1] Bioimaging Research Team, Korea Basic Science Institute, 28119, Cheongju, South Korea;Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 06351, Seoul, South Korea;Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, 06351, Seoul, South Korea;Medical Device R&D Center, Seoul National University Bundang Hospital, 13605, Seongnam, Gyeonggi-do, South Korea;Moogene Medi Co. Ltd., Gwankyo-ro 147, Gyeonggi-Bio-Center, Yeongtong-gu, 16229, Suwon, South Korea;Nanopharmacy Lab., College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 Worldcup-ro, Yeongtong-gu, 16499, Suwon, South Korea;Nanopharmacy Lab., College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 Worldcup-ro, Yeongtong-gu, 16499, Suwon, South Korea;Moogene Medi Co. Ltd., Gwankyo-ro 147, Gyeonggi-Bio-Center, Yeongtong-gu, 16229, Suwon, South Korea;

关键词: Melanin nanoparticle;    MRI;    CT;    SPECT;    Cancer imaging;   

DOI  :  10.1186/s12951-017-0304-3

 received in 2017-04-09, accepted in 2017-09-23,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMultimodal nanomaterials are useful for providing enhanced diagnostic information simultaneously for a variety of in vivo imaging methods. According to our research findings, these multimodal nanomaterials offer promising applications for cancer therapy.ResultsMelanin nanoparticles can be used as a platform imaging material and they can be simply produced by complexation with various imaging active ions. They are capable of specifically targeting epidermal growth factor receptor (EGFR)-expressing cancer cells by being anchored with a specific antibody. Ion-doped melanin nanoparticles were found to have high bioavailability with long-term stability in solution, without any cytotoxicity in both in vitro and in vivo systems.ConclusionBy combining different imaging modalities with melanin particles, we can use the complexes to obtain faster diagnoses by computed tomography deep-body imaging and greater detailed pathological diagnostic information by magnetic resonance imaging. The ion-doped melanin nanoparticles also have applications for radio-diagnostic treatment and radio imaging-guided surgery, warranting further proof of concept experimental.

【 授权许可】

CC BY   
© The Author(s) 2017