Growth hormone response to submaximal doses of ghrelin remains unchanged during the follicular phase of the cycle

Reproductive Biology and Endocrinology

Research

Panagiotis Georgoulias¹  Maria Malandri²  George Anifandis²  Konstantinos Dafopoulos²  Ioannis E Messinis²  Christina I Messini² 

[1] Department of Nuclear Medicine, School of Health Sciences, Faculty of Medicine, University of Thessalia, Larissa, Greece;Department of Obstetrics and Gynaecology, School of Health Sciences, Faculty of Medicine, University of Thessalia, Larissa, Greece;

关键词: Ghrelin;    Growth hormone;    Estradiol;    Menstrual cycle;   

DOI  :  10.1186/1477-7827-11-36

 received in 2013-03-11, accepted in 2013-05-06,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPrevious data have shown that ghrelin-induced growth hormone (GH) secretion is augmented in women by exogenous but not by endogenous estrogens. The purpose of this study was to examine the response of GH to low-dose scheme of ghrelin administration in relation to physiological changes in estradiol levels during the normal menstrual cycle.MethodsTen normally cycling women were studied in two menstrual cycles. Two consecutive dosages of ghrelin (0.15 μg/kg and 0.30 μg/kg) were injected intravenously at 0 and 90 min in the early and late follicular phases of one cycle. Saline was injected in the preceding cycle. Blood samples were taken at −15, 0, 30, 60, 90, 120, 150 and 180 min. The GH response was assessed.ResultsSerum estradiol concentrations were significantly higher in the late than in the early follicular phase. After ghrelin, but not after saline administration, plasma ghrelin and serum GH levels increased significantly in both phases, peaking at 30 min and 120 min. The peak value at 120 min was significantly higher than at 30 min (P<0.001). There were no significant differences in ghrelin and GH levels between the two phases at all time points.ConclusionsThe present results show no difference in GH response to two consecutive submaximal doses of ghrelin between the early and the late follicular phase of the cycle. It is suggested that estradiol is not possibly involved in the physiological process that regulates ghrelin-induced GH secretion in women during the normal menstrual cycle.

【 授权许可】

Unknown   
© Messini et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.