Growth Hormone Secretory Dynamics Over the Menstrual Cycle

Endocrine Journal

CRAIG A. JAFFE¹  WENSHENG GUO²  KATHERINE KRUEGER¹  ARIEL L. BARKAN¹  IKUKO SUGAHARA¹  BLANCA OCAMPO-LIM¹  ROBERTA DEMOTT-FRIBERG¹ 

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, Department of Veterans Affairs Medical Center;Department of Biostatistics, School of Public Health, University of Michigan Ann Arbor

关键词: Pituitary;    Growth hormone;    Menstrual cycle;    Growth hormone-releasing hormone;    Estrogen;   

DOI  :  10.1507/endocrj.47.549

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(33)Cited-By(4)Whether GH secretion in women varies over the menstrual cycle is uncertain. Previous investigations have led to conflicting conclusions; some studies suggested that there is an estrogen mediated rise in GH during the periovulatory (PO) and luteal (L) phases whereas others indicated no change in GH axis over the cycle. Differences in conclusions could relate to heterogeneity of the study populations, GH sampling paradigms or sensitivity of the GH assays used. In order to investigate whether GH secretion varied over the cycle, 24-h GH profiles using every 10-min sampling were obtained in 6 ovulatory women during the early follicular (EF), PO and L phases of the cycle. The TSH response to TRH, GH response to GRH and fasting plasma IGF-I were measured on each occasion. There was a trend toward higher integrated GH concentration (IGHC) during the PO phase, although this difference was not statistically significant (3284±721 vs 4542±872 vs 4071 ±699μg/min/L; EF vs PO vs L; p=0.09). Similarly, deconvolution estimated GH secretion did not vary over the cycle (p=0.56). There were no differences in GH pulse amplitude or frequency. There were no correlations between IGHC and sex steroids. Serum IGF-I was constant over the cycle (272±38 vs 277±31 vs 265±38μg/L; p=0.89). The TSH response to TRH and GH response to GRH did not vary over the cycle. We concluded that the effect of changes in the ovarian steroid milieu on the GH axis during spontaneous menstrual cycles is minimal.

【 授权许可】

Unknown