A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics

Cardiovascular Diabetology

Original Investigation

Philip Howard¹  KaWah Li¹  Dauda A. S. Bappa¹  Katherine E. Beaney¹  Steve E. Humphries¹  Claire E. Ward²  John V. Lamont²  Martin A. Crockard²  Dwaine R. Vance²  Nadine McGale³  Anna K. Davies³  Stanton Newman³  Shashivadan P. Hirani³ 

[1] British Heart Foundation Laboratories, Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, University Street, London, UK;Molecular Diagnostics Group, Randox Laboratories Ltd, Crumlin, UK;School of Health Sciences, City University London, Northampton Square, London, UK;

关键词: Type 2 diabetes;    Coronary heart disease;    Gene score;    UKPDS score;    Risk prediction;   

DOI  :  10.1186/s12933-016-0457-7

 received in 2016-08-11, accepted in 2016-09-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits.MethodsTen-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randox’s Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185).ResultsOverall, 10-year CHD risk ranged from 2–72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the CoRDia SMI plus risk group (n = 66) (p = 0.80) and a sample of UK healthy men (n = 1360). The GS was also associated with LDL-cholesterol (p = 0.05) and family history (p = 0.03) in a sample of UK healthy men (n = 1360).ConclusionsCHD risk is high in this group of T2D subjects. The risk array is an accurate genotyping assay, and is suitable for estimating an individual’s genetic CHD risk.Trial registration This study has been registered at ClinicalTrials.gov; registration identifier NCT01891786

【 授权许可】

CC BY   
© The Author(s) 2016