A retrospective cross-sectional study: fresh cycle endometrial thickness is a sensitive predictor of inadequate endometrial thickness in frozen embryo transfer cycles

Reproductive Biology and Endocrinology

Research

Patricia T Jimenez¹  Samantha B Schon²  Emily S Jungheim²  Randall R Odem²  Valerie S Ratts² 

[1] Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA;Department of Obstetrics and Gynecology, Washington University School of Medicine, Washington, DC, USA;

关键词: Endometrial thickness;    Frozen embryo transfer;    Estrogen supplementation;   

DOI  :  10.1186/1477-7827-11-35

 received in 2013-02-01, accepted in 2013-05-06,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study is to assess predictors of inadequate endometrial cavity thickness (ECT), defined as < 8 mm, in frozen embryo transfer (FET) cycles.MethodsThis is a retrospective cross-sectional study at an academic fertility center including 274 women who underwent their first endometrial preparation with estradiol for autologous FET in our center from 2001-2009. Multivariable logistic regression was performed to determine predictors of inadequate endometrial development in FET cycles.ResultsNeither age nor duration of estrogen supplementation were associated with FET endometrial thickness. Lower body mass index, nulliparity, previous operative hysteroscopy and thinner fresh cycle endometrial lining were associated with inadequate endometrial thickness in FET cycles. A maximum thickness of 11.5 mm in a fresh cycle was 80% sensitive and 70% specific for inadequate frozen cycle thickness.ConclusionsPrevious fresh cycle endometrial cavity thickness is associated with subsequent FET cycle endometrial cavity thickness. Women with a fresh cycle thickness of 11.5 mm or less may require additional intervention to achieve adequate endometrial thickness in preparation for a frozen cycle.

【 授权许可】

CC BY   
© Jimenez et al.; licensee BioMed Central Ltd. 2013