A retrospective cross-sectional study: fresh cycle endometrial thickness is a sensitive predictor of inadequate endometrial thickness in frozen embryo transfer cycles

Reproductive Biology and Endocrinology

Emily S Jungheim¹  Valerie S Ratts¹  Randall R Odem¹  Samantha B Schon¹  Patricia T Jimenez² 

[1] Department of Obstetrics and Gynecology, Washington University School of Medicine, Washington, DC, USA;Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

关键词: Estrogen supplementation;    Frozen embryo transfer;    Endometrial thickness;   

Others  :  812002
DOI  :  10.1186/1477-7827-11-35

 received in 2013-02-01, accepted in 2013-05-06,  发布年份 2013

【 摘 要 】

Background

The purpose of this study is to assess predictors of inadequate endometrial cavity thickness (ECT), defined as < 8 mm, in frozen embryo transfer (FET) cycles.

Methods

This is a retrospective cross-sectional study at an academic fertility center including 274 women who underwent their first endometrial preparation with estradiol for autologous FET in our center from 2001-2009. Multivariable logistic regression was performed to determine predictors of inadequate endometrial development in FET cycles.

Results

Neither age nor duration of estrogen supplementation were associated with FET endometrial thickness. Lower body mass index, nulliparity, previous operative hysteroscopy and thinner fresh cycle endometrial lining were associated with inadequate endometrial thickness in FET cycles. A maximum thickness of 11.5 mm in a fresh cycle was 80% sensitive and 70% specific for inadequate frozen cycle thickness.

Conclusions

Previous fresh cycle endometrial cavity thickness is associated with subsequent FET cycle endometrial cavity thickness. Women with a fresh cycle thickness of 11.5 mm or less may require additional intervention to achieve adequate endometrial thickness in preparation for a frozen cycle.

【 授权许可】

   
2013 Jimenez et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Loutradi KE, Kolibianakis EM, Venetis CA, Papanikolaou EG, Pados G, Bontis I, Tarlatzis BC: Cryopreservation of human embryos by vitrification or slow freezing: a systematic review and meta-analysis. Fertil Steril 2008, 90:186-193.
• [2]Saito H, Ishida GM, Kaneko T, Kawachiya S, Ohta N, Takahashi T, Saito T, Hiroi M: Application of vitrification to human embryo freezing. Gynecol Obstet Invest 2000, 49:145-149.
• [3]Soares SR, Velasco JA, Fernandez M, Bosch E, Remohi J, Pellicer A, Simon C: Clinical factors affecting endometrial receptiveness in oocyte donation cycles. Fertil Steril 2008, 89:491-501.
• [4]Ghobara T, Vandekerckhove P: Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev 2008, CD003414.
• [5]Abdalla HI, Brooks AA, Johnson MR, Kirkland A, Thomas A, Studd JW: Endometrial thickness: a predictor of implantation in ovum recipients? Hum Reprod 1994, 9:363-365.
• [6]Basir GS, Basir GS, O WS, So WW, Ng EH, Ho PC: Evaluation of cycle-to-cycle variation of endometrial responsiveness using transvaginal sonography in women undergoing assisted reproduction. Ultrasound Obstet Gynecol 2002, 19:484-489.
• [7]Dessolle L, Darai E, Cornet D, Rouzier R, Coutant C, Mandelbaum J, Antoine JM: Determinants of pregnancy rate in the donor oocyte model: a multivariate analysis of 450 frozen-thawed embryo transfers. Hum Reprod 2009, 24:3082-3089.
• [8]Gonen Y, Casper RF, Jacobson W, Blankier J: Endometrial thickness and growth during ovarian stimulation: a possible predictor of implantation in in vitro fertilization. Fertil Steril 1989, 52:446-450.
• [9]von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP: The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007, 370:1453-1457.
• [10]Bromer JG, Aldad TS, Taylor HS: Defining the proliferative phase endometrial defect. Fertil Steril 2009, 91:698-704.
• [11]Paulson RJ: Hormonal induction of endometrial receptivity. Fertil Steril 2011, 96:530-535.
• [12]Singh N, Bahadur A, Mittal S, Malhotra N, Bhatt A: Predictive value of endometrial thickness, pattern and sub-endometrial blood flows on the day of hCG by 2D doppler in in-vitro fertilization cycles: a prospective clinical study from a tertiary care unit. J Hum Reprod Sci 2011, 4:29-33.
• [13]Chen SL, Wu FR, Luo C, Chen X, Shi XY, Zheng HY, Ni YP: Combined analysis of endometrial thickness and pattern in predicting outcome of in vitro fertilization and embryo transfer: a retrospective cohort study. Reprod Biol Endocrinol 2010, 8:30. BioMed Central Full Text
• [14]Wada I, Hsu CC, Williams G, Macnamee MC, Brinsden PR: The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod 1994, 9:1954-1957.
• [15]Letur-Konirsch H, Guis F, Delanian S: Uterine restoration by radiation sequelae regression with combined pentoxifylline-tocopherol: a phase II study. Fertil Steril 2002, 77:1219-1226.
• [16]Acharya S, Yasmin E, Balen AH: The use of a combination of pentoxifylline and tocopherol in women with a thin endometrium undergoing assisted conception therapies–a report of 20 cases. Hum Fertil (Camb) 2009, 12:198-203.
• [17]Takasaki A, Tamura H, Miwa I, Taketani T, Shimamura K, Sugino N: Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertil Steril 2010, 93:1851-1858.
• [18]Gleicher N, Vidali A, Barad DH: Successful treatment of unresponsive thin endometrium. Fertil Steril 2011, 95(2123):e2113-2127.