E-cadherin expression phenotypes associated with molecular subtypes in invasive non-lobular breast cancer: evidence from a retrospective study and meta-analysis

World Journal of Surgical Oncology

Research

Miao Deng¹  De-Chun Liu¹  Jiang-Bo Liu¹  Dong-Feng Ge²  Jian-Qiang Mi²  Xiao-Shan Feng³  Chen-Yi Feng³ 

[1] Department of General Surgery, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, 471003, Luoyang, China;Department of Pathology, First Affiliated Hospital, College of Clinical Medicine, , Henan University of Science and Technology, 471003, Luoyang, China;Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, 471003, Luoyang, China;

关键词: E-cadherin;    Breast cancer;    Immunohistochemistry;    Molecular subtypes;    Meta-analysis;   

DOI  :  10.1186/s12957-017-1210-8

 received in 2017-01-31, accepted in 2017-07-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThis retrospective study and meta-analysis was designed to explore the relationship between E-cadherin (E-cad) expression and the molecular subtypes of invasive non-lobular breast cancer, especially in early-stage invasive ductal carcinoma (IDC).MethodsA total of 156 post-operative cases of early-stage IDCs were retrospectively collected for the immunohistochemistry (IHC) detection of E-cad expression. The association of E-cad expression with molecular subtypes of early-stage IDCs was analyzed. A literature search was conducted in March 2016 to retrieve publications on E-cad expression in association with molecular subtypes of invasive non-lobular breast cancer, and a meta-analysis was performed to estimate the relational statistics.ResultsE-cad was expressed in 82.7% (129/156) of early-stage IDCs. E-cad expression was closely associated with the molecular types of early-stage IDCs (P < 0.050); moreover, the molecular subtypes were an independent factor influencing E-cad expression in early-stage IDCs. A total of 12 observational studies (including our study) were included in the meta-analysis. The meta-analytical results show a significantly greater risk of E-cad expression loss in triple-negative breast cancer (TNBC) than in other molecular subtypes (TNBC vs. luminal A: RR = 3.45, 95% CI = 2.79–4.26; TNBC vs. luminal B: RR = 2.41, 95% CI = 1.49–3.90; TNBC vs. HER2-enriched: RR = 1.95, 95% CI = 1.24–3.07).ConclusionsEarly-stage IDCs or invasive non-lobular breast cancers with the TNBC molecular phenotype have a higher risk for the loss of E-cad expression than do tumors with non-TNBC molecular phenotypes, suggesting that E-cad expression phenotypes were closely related to molecular subtypes and further studies are needed to clarify the underlying mechanism.

【 授权许可】

CC BY   
© The Author(s). 2017