CHD1L Protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival

BMC Cancer

Research Article

Guo-Fen Yang¹  Juan Zhou¹  Wei-Peng He¹  Hsiang-Fu Kung²  Xin-Yuan Guan³  Dan Xie³  Mu-Yan Cai³  Xiang-Shen Xiao³  Yi-Ji Liao³ 

[1] Department of Gynecology, the First Affiliated Hospital, Sun Yat-Sen University, No. 78, Zhongshan Road II, 510080, Guangzhou, China;Department of Oncology, the University of Hong Kong, Hong Kong, China;State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, No. 651, Dongfeng Road East, 510060, Guangzhou, China;

关键词: Ovarian Cancer;    Ovarian Carcinoma;    Receiver Operate Characteristic Curve;    Positive Expression;    Figo Stage;   

DOI  :  10.1186/1471-2407-12-437

 received in 2012-01-16, accepted in 2012-09-26,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundOur recent studies suggested that the chromodomain helicase DNA binding protein 1-like (CHD1L) gene plays an oncogenic role in human hepatocellular carcinoma. However, the status of CHD1L protein expression in ovarian cancer and its clinical/prognostic significance are obscure.MethodsIn this study, immunohistochemistry (IHC) for CHD1L was performed on a tissue microarray (TMA) containing 102 primary ovarian carcinomas and 44 metastatic lesions (omental metastasis). Receiver-operator curve (ROC) analysis was used to evaluate patients’ survival status.ResultsThere is an augmented tendency of CHD1L expression in ovarian carcinoma metastasis than in primary lesions (P<0.05). A significant association was found between positive expression of CHD1L and tumors histological type (P <0.05). By univariate survival analysis of the ovarian carcinoma cohorts, positive expression of CHD1L was significantly correlated with shortened patient survival (mean 66.7 months versus 97.4 months, P<0.05). Moreover, CHD1L expression was evaluated to be a significant and independent prognostic factor in multivariate analysis (P<0.05).ConclusionsThese findings provide evidence that positive expression of CHD1L protein is significantly correlated with the metastasis proceeding of ovarian carcinoma, and CHD1L protein expression, as examined by IHC, may act as a novel prognostic biomarker for patients with ovarian carcinoma.

【 授权许可】

Unknown   
© He et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.