The protective effect of Malva sylvestris on rat kidney damaged by vanadium

Lipids in Health and Disease

Research

Ahlem Soussi¹  Abdelfattah El Feki¹  Wafa Marouane²  Sofiane Bezzine³  Jean-Claude Murat⁴ 

[1] Laboratoire d'Ecophysiologie Animale, Faculté des Sciences, University of Sfax, Route de Soukra, 3038, Sfax, Tunisia;Laboratoire d'Ecophysiologie Animale, Faculté des Sciences, University of Sfax, Route de Soukra, 3038, Sfax, Tunisia;Laboratoire de Biochimie et de Génie Enzymatique des Lipases, Ecole Nationale d'Ingénieurs, University of Sfax, Route de Soukra, 3038, Sfax, Tunisia;Laboratoire de Biochimie, Institut Supérieur de Biotechnologie de Sfax, University of Sfax, Route de Soukra, 3038, Sfax, Tunisia;Laboratoire de Biochimie et de Génie Enzymatique des Lipases, Ecole Nationale d'Ingénieurs, University of Sfax, Route de Soukra, 3038, Sfax, Tunisia;Laboratoire de Biochimie, Institut Supérieur de Biotechnologie de Sfax, University of Sfax, Route de Soukra, 3038, Sfax, Tunisia;Laboratoire de Biologie Cellulaire, Faculté de Médecine, Toulouse, France;

关键词: Ammonium metavanadate;    Malva sylvestris;    nephrotoxicity;    oxidative stress;    antioxidant enzymes;   

DOI  :  10.1186/1476-511X-10-65

 received in 2011-02-04, accepted in 2011-04-23,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe protective effect of the common mallow (Malva sylvestris) decoction on renal damages in rats induced by ammonium metavanadate poisoning was evaluated. On the one hand, vanadium toxicity is associated to the production of reactive oxygen species, causing a lipid peroxidation and an alteration in the enzymatic antioxidant defence. On the other hand, many medicinal plants are known to possess antioxidant and radical scavenging properties, thanks to the presence of flavonoids. These properties were confirmed in Malva sylvestris by two separate methods; namely, the Diphenyl-2-picrylhydrazyl assay and the Nitroblue Tetrazolium reduction assay.ResultsIn 80 rats exposed to ammonium metavanadate (0.24 mmol/kg body weight in drinking water) for 90 days, lipid peroxidation levels and superoxide dismutase, catalase and glutathione peroxidase activities were measured in kidney. A significant increase in the formation of free radicals and antioxidant enzyme activities was noticed. In addition, a histological examination of kidney revealed a structural deterioration of the renal cortical capsules and a shrinking of the Bowman space. In animals intoxicated by metavanadate but also given a Malva sylvestris decoction (0.2 g dry mallow/kg body weight), no such pathologic features were observed: lipid peroxidation levels, antioxidant enzyme activities and histological features appeared normal as compared to control rats.ConclusionMalva sylvestris is proved to have a high antioxidative potential thanks to its richness in phenolic compounds.

【 授权许可】

Unknown   
© Marouane et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.