Sleep disturbances and quality of life in postoperative management after esophagectomy for esophageal cancer

World Journal of Surgical Oncology

Research

Matteo Parotto¹  Fabio Baratto¹  Elisabetta Saraceni¹  Matteo Cagol²  Marco Scarpa²  Eleonora Pinto²  Carlo Castoro²  Anna Da Roit²  Luca M Saadeh²  Rita Alfieri²  Elisa Pizzolato² 

[1] ISTAR1 Intensive Care Unit, University of Padova, via Giustiniani 2, 35128, Padova, Italy;Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), via Gattamelata 64, 35128, Padova, Italy;

关键词: Esophageal cancer;    Esophagectomy;    Postoperative management;    Sleep disturbance;   

DOI  :  10.1186/1477-7819-12-156

 received in 2014-03-02, accepted in 2014-05-06,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe aims of this prospective study were to analyze the predictors of postoperative sleep disturbance after esophagectomy for cancer and to identify patients at risk for postoperative hypnotic administration.MethodsSixty two consecutive patients who underwent cancer-related esophagectomy were enrolled in this study from May 2011 to February 2012. Data about perioperative management, postoperative complications, ICU stay, and vasopressor, hypnotic, and painkiller administration were retrieved. The EORTC QLQ-C30 was used and global quality of life (QL2 item) and sleep disturbance (SL item) were the primary endpoints. Univariate and multivariate analyses were performed.ResultsPostoperative request of hypnotics independently predicted bad quality of life outcome. Sleep disturbance after esophagectomy was independently predicted by the duration of dopamine infusion in the ICU and the daily request of benzodiazepines. Even in this case, only sleep disturbance at diagnosis revealed to be an independent predictor of hypnotic administration need. ROC curve analysis showed that sleep disturbance at diagnosis was a good predictor of benzodiazepine request (AUC = 73%, P = 0.02).ConclusionsThe use of vasopressors in the ICU affects sleep in the following postoperative period and the use of hypnotics is neither completely successful nor lacking in possible consequences. Sleep disturbance at diagnosis can successfully predict patients who can develop sleep disturbance during the postoperative period.

【 授权许可】

CC BY   
© Scarpa et al.; licensee BioMed Central Ltd. 2014