Sleep disturbances and quality of life in postoperative management after esophagectomy for esophageal cancer

World Journal of Surgical Oncology

Carlo Castoro²  Fabio Baratto¹  Elisabetta Saraceni¹  Matteo Cagol²  Rita Alfieri²  Elisa Pizzolato²  Anna Da Roit²  Matteo Parotto¹  Luca M Saadeh²  Eleonora Pinto²  Marco Scarpa² 

[1] ISTAR1 Intensive Care Unit, University of Padova, via Giustiniani 2, 35128 Padova, Italy;Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), via Gattamelata 64, 35128 Padova, Italy

关键词: Sleep disturbance;    Postoperative management;    Esophagectomy;    Esophageal cancer;   

Others  :  811508
DOI  :  10.1186/1477-7819-12-156

 received in 2014-03-02, accepted in 2014-05-06,  发布年份 2014

【 摘 要 】

Background

The aims of this prospective study were to analyze the predictors of postoperative sleep disturbance after esophagectomy for cancer and to identify patients at risk for postoperative hypnotic administration.

Methods

Sixty two consecutive patients who underwent cancer-related esophagectomy were enrolled in this study from May 2011 to February 2012. Data about perioperative management, postoperative complications, ICU stay, and vasopressor, hypnotic, and painkiller administration were retrieved. The EORTC QLQ-C30 was used and global quality of life (QL2 item) and sleep disturbance (SL item) were the primary endpoints. Univariate and multivariate analyses were performed.

Results

Postoperative request of hypnotics independently predicted bad quality of life outcome. Sleep disturbance after esophagectomy was independently predicted by the duration of dopamine infusion in the ICU and the daily request of benzodiazepines. Even in this case, only sleep disturbance at diagnosis revealed to be an independent predictor of hypnotic administration need. ROC curve analysis showed that sleep disturbance at diagnosis was a good predictor of benzodiazepine request (AUC = 73%, P = 0.02).

Conclusions

The use of vasopressors in the ICU affects sleep in the following postoperative period and the use of hypnotics is neither completely successful nor lacking in possible consequences. Sleep disturbance at diagnosis can successfully predict patients who can develop sleep disturbance during the postoperative period.

【 授权许可】

   
2014 Scarpa et al.; licensee BioMed Central Ltd.

【 图 表 】

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