Associations of genetic variation in CASP3 gene with noise-induced hearing loss in a Chinese population: a case–control study

Environmental Health

Research

Haiyan Ma¹  Liangwen Xu¹  Mingjian Qi¹  Juntao Ni¹  Lei Yang¹  Yinyin Wu¹  Chengjian Cao²  Yuxian Shao² 

[1] Department of Preventive Medicine, School of Medicine, Hangzhou Normal University, 310018, Zhejiang, Hangzhou, People’s Republic of China;Hangzhou hospital for prevention and treatment of occupational diseases, 310014, Zhejiang, Hangzhou, People’s Republic of China;

关键词: Genetic susceptibility;    CASP3;    Single-nucleotide polymorphism/SNP;    Noise-induced hearing loss/NIHL;   

DOI  :  10.1186/s12940-017-0280-y

 received in 2017-01-03, accepted in 2017-06-19,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundNoise-induced hearing loss (NIHL) is a complex disease caused by environmental and genetic risk factors. This study explored the relationship between the genetic variations in the CASP gene and the risk of developing NIHL among Chinese workers exposed to occupational noise.MethodsA case–control study of 272 NIHL workers and 272 normal-hearing workers matched for age, sex and years of noise exposure was conducted. Fifteen single-nucleotide polymorphisms (SNP) in the CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, CASP9, CASP10 and CASP14 genes were genotyped using the polymerase chain reaction–ligase detection reaction method. Using conditional logistic regression models, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of genetic variations associated with NIHL risk were calculated.ResultsTwo SNPs in the CASP3 gene were associated with NIHL risk. For rs1049216, TT genotype was associated with a decreased risk of NIHL (OR = 0.246, 95% CI = 0.069–0.886) when compared with the CC genotype. For rs6948, the AC and CC genotype were associated with a decreased NIHL risk (OR = 0.568, 95% CI = 0.352–0.916) compared with AA genotype. There were joint effects of working time and CASP3 polymorphisms on NIHL risk (P < 0.05).ConclusionsGenetic variations in the CASP3 gene and the joint effects of working time and CASP3 polymorphisms may modify the risk of developing NIHL.

【 授权许可】

CC BY   
© The Author(s). 2017