Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study

Environmental Health

Research

Yi Liu¹  Yimin Zhu¹  Lei Zhang²  Xuchu Wang²  Ou Wu²  Xuhui Zhang²  CaiXia Jiang²  Yuyong Xia²  Zhangping Yang²  Luoxian Yang²  Qiang Wang²  Yanjuan Chen³ 

[1] Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, 388 Yu-Hang-Tang Road, 310058, Hangzhou, Zhejiang, P.R. China;Hangzhou Center for Disease Control and Prevention, 310021, Hangzhou, P.R. China;Hangzhou Hospital for Prevention and Treatment of Occupational Diseases, 310014, Hangzhou, Zhejiang, P.R. China;

关键词: Noise exposure;    Genetic susceptibility;    EYA4;    GRHL2;    DFNA5;    Single-nucleotide polymorphism/SNP;   

DOI  :  10.1186/s12940-015-0063-2

 received in 2015-07-14, accepted in 2015-09-09,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundBoth environmental and genetic factors are attributable to the incidence of noise-induced hearing loss (NIHL). The purpose of this study was to examine the associations between genetic variations in the EYA4, GRHL2 and DFNA5 genes and the risk to noise-induced hearing loss (NIHL) in a Chinese population.MethodsA case–control study was conducted with 476 NIHL workers and 475 normal hearing workers matched with gender, years of noise exposure, and intensity of noise exposure. Twelve tag single-nucleotide polymorphisms (SNP) in the EYA4, GRHL2 and DFNA5 genes were genotyped using nanofluidic dynamic arrays on the Fluidigm platform. Multiple logistic regression was used to analyze the associations of genetic variations with NIHL adjusted by age, smoking/drinking status, and cumulative noise exposure and their interactions with noise exposure.ResultsThe SNPs of rs3777781and rs212769 in the EYA4 gene were significantly associated with NIHL risk. In rs3777781, comparing with the subjects carrying with TT types, the carriers with AT and AA genotypes had the decreased risk of NIHL (OR = 0.721, 95 % CI = 0.522 - 0.996). In rs212769, the AG and AA carriers had increased NIHL risk (OR = 1.430, 95 % CI = 1.014 - 2.016) compared with the subjects with GG genotype. Rs666026 in the associated GRHL2 gene and rs2521758 in the DFNA5 gene were marginally t associated with NIHL (P = 0.065 and 0.052, respectively). Rs2521758 and rs212769 had significantly interacted with noise exposure (P < 0.05).ConclusionsGenetic variations in the EYA4, GRHL2 and DFNA5 genes and their interactions with occupational noise exposure may play an important role in the incidence of NIHL.

【 授权许可】

CC BY   
© Zhang et al. 2015