Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses

Lipids in Health and Disease

Research

Sophie Mavrogeni¹  Genovefa Kolovou²  Antonia Kalogiani³  Georgios Vasilopoulos³  Christina Marvaki³  Apostolia Marvaki⁴  Vana Kolovou⁴  Dimitrios Degiannis⁴  Agathi Karakosta⁵ 

[1] 1st Cardiology Department, Onassis Cardiac Surgery Center Athens, Athens, Greece;1st Cardiology Department, Onassis Cardiac Surgery Center Athens, Athens, Greece;Onassis Cardiac Surgery Center, 356 Sygrou Ave 176 74, Athens, Greece;Department of Nursing, A' Technological Educational Institute of Athens, Athens, Greece;Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Athens, Greece;Thriassio General Hospital, Attica, Magoula, Greece;

关键词: Lipid Profile;    High Density Lipoprotein Cholesterol;    High Density Lipoprotein Cholesterol Level;    ABCA1 Gene;    Blood Lipid Level;   

DOI  :  10.1186/1476-511X-11-62

 received in 2012-03-20, accepted in 2012-06-05,  发布年份 2012

来源: Springer

【 摘 要 】

ObjectiveOne of the important proteins involved in lipid metabolism is the ATP-binding cassette transporter A1 (ABCA1) encoding by ABCA1 gene. In this study we evaluated the single nucleotide polymorphisms (SNPs) of ABCA1 gene. We analyzed SNPs in chromosome 9 such as rs2230806 (R219K) in the position 107620867, rs2230808 (R1587K) in the position 106602625 and rs4149313 (I883M) in the position 106626574 according to gender and lipid profile of Greek nurses.MethodsThe study population consisted of 447 (87 men) unrelated nurses who were genotyped for ABCA1 gene polymorphisms. Additionally, lipid profile [total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-C) and apolipoprotein A1] was evaluated.ResultsThe distribution of all three studied ABCA1 gene polymorphisms did not differ according to gender. However, only R219K genotype distribution bared borderline statistical significance (p = 0.08) between the two studied groups. Moreover, allele frequencies of R219K, R1587K and I88M polymorphisms did not differ according to gender. In general, blood lipid levels did not seem to vary according to ABCA1 gene polymorphisms, when testing all subjects or when testing only men or only women. However, a significant difference of LDL-C distribution was detected in all subjects according to R1587K genotype, indicating lower LDL-C levels with KK polymorphism (p = 0.0025). The above difference was solely detected on female population (p = 0.0053).ConclusionsThe ABCA1 gene polymorphisms frequency, distribution and lipid profile did not differ according to gender. However, in the female population the KK genotype of R1587K gene indicated lower LDL-C levels. Further studies, involving a higher number of individuals, are required to clarify genes and gender contribution.

【 授权许可】

CC BY   
© Kolovou et al.; licensee BioMed Central Ltd. 2012