Low cholesteryl ester transfer protein and phospholipid transfer protein activities are the factors making tree shrew and beijing duck resistant to atherosclerosis

Lipids in Health and Disease

Research

Bing Zhou¹  Hui-rong Liu²  Bao-sheng Chen³  Gang Wu³ 

[1] Beijing Center for ADR Monitoring, 100011, Beijing, China;College of Life Sciences, Inner Mongolia Agricultural University, 010018, Hohhot, China;National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 100005, Beijing, China;

关键词: High Density Lipoprotein Cholesterol;    Cholesteryl Ester Transfer Protein;    High Density Lipoprotein Cholesterol Level;    Tree Shrew;    High Density Lipoprotein Particle;   

DOI  :  10.1186/1476-511X-9-114

 received in 2010-08-20, accepted in 2010-10-12,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundTree shrew and beijing duck are regarded as animal models resistant to atherosclerosis (AS). This study was carried out to discover the potential mechanism.MethodsBlood samples were collected from healthy men and male animals. Plasma lipid profile and activities of cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) were measured, compared and analyzed in human, tree shrew, and Beijing duck.ResultsThe results showed that there were species differences on plasma lipid profile and activities of CETP and PLTP in the three species. Compared with human, tree shrew and beijing duck had higher high density lipoprotein cholesterol (HDL-C)/total cholesterol (TC) and HDL-C/low density lipoprotein cholesterol (LDL-C) ratios, but lower CETP and PLTP activities. In the three species, CETP and PLTP activities were negatively related with the ratio of HDL-C/LDL-C.ConclusionsThe present study suggested that low plasma CETP and PLTP activities may lead to a high HDL-C/LDL-C ratio and a high resistance to AS finally in tree shrew and beijing duck. Moreover, low PLTP activity may also make the animals resistant to AS by the relative high vitamin E content of apoB-containing lipoproteins and high anti-inflammatory and antioxidative properties of HDL particles. A detailed study in the future is recommended.

【 授权许可】

CC BY   
© Liu et al; licensee BioMed Central Ltd. 2010