Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study

Lipids in Health and Disease

Research

Ahmad Reza Shamshiri¹  Mohammad Ali Kashani Farid²  Fereydoun Siassi²  Fereidoun Azizi³  Mehdi Hedayati³  Maryam S Daneshpour⁴ 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, I.R. Iran;Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, I.R.Iran;Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran;Obesity Research Center, Research Institute for endocrine sciences, Shaheed Beheshti University of Medical Sciences, Tehran, I.R. Iran;

关键词: High Density Lipoprotein Cholesterol;    Cholesteryl Ester Transfer Protein;    Hepatic Lipase;    High Density Lipoprotein Cholesterol Level;    High Density Lipoprotein Cholesterol Concentration;   

DOI  :  10.1186/1476-511X-9-96

 received in 2010-07-21, accepted in 2010-09-07,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundLow level of high density lipoprotein cholesterol (HDL-C) has high prevalence in the Tehran Lipid and Glucose Study (TLGS) cohort. About 50% of the inter-individual variation in serum HDL-C levels is genetically determined. Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and serum concentration of the HDL-C.ObjectivesTo determine the association between Taq1B polymorphism in CETP gene and -514C/T polymorphism in LIPC gene with serum lipid levels and lipid peroxidation in a subgroup of the TLGS population.ResultsSerum HDL-C level had significant association with CETP Taq1B polymorphism and B2B2 subjects had the highest HDL-C levels compared to B2B1 and B1B1 genotypes (37.9 vs. 36.9 and 35.3 mg/dl, respectively; P = 0.01). However, carriers of "B1" allele, in comparison to the non carriers (B2B2), had significantly lower levels of TC (200.1 vs. 215.2 mg/dl; P = 0.005), HDL-C (35.8 vs. 37.9 mg/dl; P = 0.009) and malondialdehyde MDA (4.5 vs. 5.0 nmol/mL; P=0.031). Carriers of the "T" allele in -514C/T polymorphism in LIPC gene had higher means of HDL-C than non carriers (37.7 vs. 35.7 mg/dl, P = 0.04). No other association was found between -514C/T polymorphism and any other serum lipids or MDA level.ConclusionThis study demonstrates the association between Taq1B and -514C/T polymorphisms in the CETP and LIPC genes with the serum HDL-C levels.

【 授权许可】

Unknown   
© Farid et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.