A nested case-control study of the effects of dust exposure, smoking on COPD in coal workers

BMC Public Health

Research

Yu Su¹  Jiaqi Chen²  Yizhan Zheng²  Jiaqi Hu²  Jian Sun²  Ziqi Zhao²  Hongmin Zhu²  Zekun Zhao²  Shengguang Yan²  Zhikang Si²  Rui Meng²  Ling Xue²  Xuelin Wang²  Hui Wang²  Haipeng Lu²  Xiaoming Li²  Huan Wang²  Jianhui Wu³ 

[1] Personnel Department, North China University of Science and Technology, Tangshan City, Hebei Province, China;School of Public Health, Caofeidian New Town, North China University of Science and Technology, No.21 Bohai Avenue, 063210, Tangshan City, Hebei Province, People’s Republic of China;School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province, China;

关键词: Coal workers;    Dust exposure;    Smoking;    COPD;    Interaction;   

DOI  :  10.1186/s12889-023-16944-6

 received in 2023-05-17, accepted in 2023-10-09,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundChronic obstructive pulmonary disease (COPD) represents a prevalent ailment, progressively surging within the ranks of coal mine laborers. The current study endeavors to elucidate the effects of dust exposure and smoking on COPD incidence amongst coal mine workers, while concurrently devising preventive strategies for this affliction.MethodA nested case–control study was conducted encompassing 1,416 participants aged ≥ 18 years, spanning the duration from (2017–2018) until 2020. A meticulous matching process yielded a cohort of 708 COPD patients, each paired with a control subject, forming a harmonious 1:1 ratio. Multiple logistic regression analysis was employed to scrutinize the associations between smoking, dust exposure with COPD among coal workers.ResultsThe COPD prevalence within the cohort of coal workers under investigation amounted to 22.66%, with an accompanying incidence density of 0.09/person-year. Following meticulous adjustment for confounding variables, it was discerned that cumulative dust exposure within the range of 47.19 ~ (OR: 1.90, 95% CI: 1.05, 3.44), 101.27 ~ (OR: 1.99, 95% CI: 1.17, 3.39), as well as smoking indices of 72 ~ (OR: 1.85, 95% CI: 1.19, 2.88), 145 ~ (OR: 1.74, 95% CI: 1.17, 2.61), 310 ~ (OR: 1.85, 95% CI: 1.23, 2.77) engender an escalated vulnerability to COPD among coal workers. Furthermore, interaction analysis discerned an absence of both multiplicative and additive interactions between dust exposure, smoking, and COPD occurrence amidst coal workers.ConclusionDust exposure and smoking were unequivocally identified as precipitating risk factors for COPD incidence within the population of coal workers, albeit devoid of any discernible interaction between these two causal agents.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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