Malaria Journal | |
Polymorphism of the merozoite surface protein-1 block 2 region in Plasmodium falciparum isolates from Mauritania | |
Research | |
Ali O Mohamed Salem O Boukhary1  Khadijetou M Lekweiry1  Mohamed Salem O Ahmedou Salem2  Lassana Konaté3  Ousmane Faye3  Mohamed OuldAbdallahi4  Magatte Ndiaye5  Babacar Faye5  Oumar Gaye5  Hervé Bogreau6  | |
[1] Laboratoire de Biotechnologie, Faculté des Sciences et Techniques, Université des Sciences, de Technologie et de Médecine, Nouakchott, PO Box 5026, Nouakchott, Mauritanie;Laboratoire de Biotechnologie, Faculté des Sciences et Techniques, Université des Sciences, de Technologie et de Médecine, Nouakchott, PO Box 5026, Nouakchott, Mauritanie;Laboratoire d’Ecologie Vectorielle et Parasitaire, Faculté des sciences et techniques, Université Cheikh Anta Diop, Dakar, Sénégal;Laboratoire d’Ecologie Vectorielle et Parasitaire, Faculté des sciences et techniques, Université Cheikh Anta Diop, Dakar, Sénégal;Service de Parasitologie et de Mycologie, Institut National de Recherches en Santé Publique, BP 695, Nouakchott, Mauritanie;Service de Parasitologie-Mycologie, Faculté de Médecine, Université Cheikh Anta Diop, Dakar, Sénégal;Unité de Parasitologie, Département d’Infectiologie de Terrain, Institut de Recherche Biomédicale des Armées, BP 7391 223, Brétigny-sur-Orge cedex, France;Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Faculté de Médecine La Timone, Aix Marseille Université, 27 boulevard Jean Moulin, 13385, Marseille cedex 5 Marseille, France;Unité de Parasitologie Institut Pasteur, BP 6010, 23 Avenue Pasteur, 97306, Cayenne cedex Guyane, France; | |
关键词: Plasmodium falciparum; Malaria; Genetic diversity; Multiplicity of infection; msp-1; Mauritania; | |
DOI : 10.1186/1475-2875-13-26 | |
received in 2013-07-13, accepted in 2014-01-21, 发布年份 2014 | |
来源: Springer | |
【 摘 要 】
BackgroundThe genetic diversity of Plasmodium falciparum has been extensively studied in various parts of the world. However, limited data are available from Mauritania. The present study examined and compared the genetic diversity of P. falciparum isolates in Mauritania.MethodsPlasmodium falciparum isolates blood samples were collected from 113 patients attending health facilities in Nouakchott and Hodh El Gharbi regions. K1, Mad20 and RO33 allelic family of msp-1 gene were determined by nested PCR amplification.ResultsK1 family was the predominant allelic type carried alone or in association with Ro33 and Mad20 types (90%; 102/113). Out of the 113 P. falciparum samples, 93(82.3%) harboured more than one parasite genotype. The overall multiplicity of infection was 3.2 genotypes per infection. There was no significant correlation between multiplicity of infection and age of patients. A significant increase of multiplicity of infection was correlated with parasite densities.ConclusionsThe polymorphism of P. falciparum populations from Mauritania was high. Infection with multiple P. falciparum clones was observed, as well as a high multiplicity of infection reflecting both the high endemicity level and malaria transmission in Mauritania.
【 授权许可】
Unknown
© Ahmedou Salem et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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RO202311106344613ZK.pdf | 360KB | download |
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]
- [35]
- [36]
- [37]
- [38]
- [39]
- [40]
- [41]
- [42]